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Dihydrocyclosporin A (CAS 59865-15-5)

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Alternate Names:
Dihydrocyclosporin A
Application:
Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A
CAS Number:
59865-15-5
Purity:
≥98%
Molecular Weight:
1204.6
Molecular Formula:
C62H113N11O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dihydrocyclosporin A is a compound closely related to cyclosporin A, which is known for its role in protein folding studies and as a reference compound in the exploration of immunosuppressive mechanisms. Researchers employ it to understand the binding and inhibition of the enzyme cyclophilin, which is involved in protein folding and intracellular signaling pathways. In structural biology, Dihydrocyclosporin A is used to study the conformational changes of proteins upon ligand binding, utilizing techniques such as X-ray crystallography and NMR spectroscopy. Additionally, it is of interest in the field of plant biology, where it aids in the study of stress responses, given its structural similarity to molecules that interact with plant metabolic pathways. Dihydrocyclosporin A also serves as a tool in biochemistry research to investigate the molecular basis of protein-protein interactions and their effects on cellular functions.


Dihydrocyclosporin A (CAS 59865-15-5) References

  1. Identification of NF-AT-like transcription factor in Schistosoma mansoni: its possible involvement in the antiparasitic action of cyclosporin A.  |  Serra, EC., et al. 1999. Mol Biochem Parasitol. 101: 33-41. PMID: 10413041
  2. Mode of action of cyclosporin A against Hymenolepis microstoma (Cestoda): relationship between cyclophilin binding and drug-induced damage.  |  McLauchlan, PE., et al. 2000. Parasitology. 121 Pt 6: 661-70. PMID: 11155937
  3. Isolation of (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine, the characteristic structural element of cyclosporins, from a blocked mutant of Tolypocladium inflatum.  |  Sanglier, JJ., et al. 1990. J Antibiot (Tokyo). 43: 707-14. PMID: 2116402
  4. Enhanced percutaneous absorption of a novel topical cyclosporin A formulation and assessment of its immunosuppressive activity.  |  Duncan, JI., et al. 1990. Br J Dermatol. 123: 631-40. PMID: 2147390
  5. Action of cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo.  |  Chappell, LH., et al. 1989. Parasitology. 98 Pt 2: 291-9. PMID: 2762040
  6. Immunohistochemical analysis of contact sensitivity reactions in the guinea-pig using novel monoclonal antibodies: the influence of topical cyclosporin A.  |  Payne, SN. and Thomson, AW. 1989. Clin Exp Immunol. 75: 444-50. PMID: 2784748
  7. An overview of the treatment of cutaneous leishmaniasis.  |  Garza-Tovar, TF., et al. 2020. Fac Rev. 9: 28. PMID: 33659960
  8. Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro.  |  Chappell, LH., et al. 1987. Antimicrob Agents Chemother. 31: 1567-71. PMID: 3435104
  9. Immunological and pharmacological monitoring in the clinical use of cyclosporin A.  |  Keown, PA., et al. 1981. Lancet. 1: 686-9. PMID: 6110913
  10. Uptake and nature of the intracellular binding of cyclosporin A in a murine thymoma cell line, BW5147.  |  Merker, MP. and Handschumacher, RE. 1984. J Immunol. 132: 3064-70. PMID: 6609967
  11. Kinetics of acid-catalyzed degradation of cyclosporin A and its analogs in aqueous solution.  |  Oliyai, R., et al. 1994. Int J Pept Protein Res. 43: 239-47. PMID: 8005746
  12. [Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity].  |  Rüegger, A., et al. 1976. Helv Chim Acta. 59: 1075-92. PMID: 950308

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dihydrocyclosporin A, 1 mg

sc-362019
1 mg
$114.00