Molecular structure of Dihydro-D-erythro-Sphingosine, CAS Number: 764-22-7
Dihydro-D-erythro-Sphingosine (CAS 764-22-7)
Alternate Names:
D-erythro-Dihydrosphingosine; D-erythro-Sphinganine, C18 chain
Application:
Dihydro-D-erythro-Sphingosine is a sphingosine biosynthetic precursor
CAS Number:
764-22-7
Molecular Weight:
301.5
Molecular Formula:
C18H39NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dihydro-D-erythro-Sphingosine is a biosynthetic precursor of sphingosine that inhibits PKC (protein kinase C) in Chinese hamster ovary cells (IC50 = 2.8 muM). Dihydro-D-erythro-Sphingosine also directly inhibits PLA2 (phospholipase A2) and PC-PLD (phospholipase D). Dihydro-D-erythro-Sphingosine is a substrate of SphK.
Dihydro-D-erythro-Sphingosine (CAS 764-22-7) References
- Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4, 5-trisphosphate. | Ching, TT., et al. 1999. J Biol Chem. 274: 8611-7. PMID: 10085097
- Angiotensin II inhibits endothelial cell motility through an AT1-dependent oxidant-sensitive decrement of nitric oxide availability. | Desideri, G., et al. 2003. Arterioscler Thromb Vasc Biol. 23: 1218-23. PMID: 12763763
- Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. | Grimm, C., et al. 2005. Mol Pharmacol. 67: 798-805. PMID: 15550678
- Measurement of phospholipase d activation in vascular smooth muscle cells. | Touyz, RM. and Schiffrin, EL. 2001. Methods Mol Med. 51: 355-62. PMID: 21331729
Inhibitor of:
Ceramide Kinase, PC-PLD, PKC, PLA2, and Ser/Thr Protein Kinase.Substrate of:
SphK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydro-D-erythro-Sphingosine, 10 mg | sc-203911 | 10 mg | $77.00 |