Dihomo-gamma-linolenic Acid (20:3, n-6) CAS: 1783-84-2
MF: C20H34O2
MW: 306.48
A polyunsaturated fatty acid.

Dihomo-γ-linolenic Acid (20:3, n-6) (CAS 1783-84-2)

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Synonym: Homo-γ-linolenic acid
Application: A polyunsaturated fatty acid
CAS Number: 1783-84-2
Purity: ≥99%
Molecular Weight: 306.48
Molecular Formula: C20H34O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Dihomo-γ-linolenic Acid (20:3, n-6) is long-chain polyunsaturated fatty acid, the natural biosynthetic precursor of prostaglandin E1 (PGE1, sc-201223), and an elongase product of γ-linolenic acid. Dihomo-γ-linolenic Acid is structurally similar to Arachidonic acid (AA, sc-200770), and both are recognized and transformed by cyclooxygenase and lipoxygenase enzymes into eicosanoid metabolites. The metabolites of AA produced in platelets, such as thromboxane A2, are proaggregatory. As Dihomo-γ-linolenic Acid and AA compete for processing by these oxidation enzymes, introduction of Dihomo-γ-linolenic Acid to platelets is correlated to suppression of AA metabolites and promotion of Dihomo-γ-linolenic Acid metabolites such as PGE1, which produces an antithrombotic effect.


References

1. Kernoff, P.B., et al. 1977. Br Med J. 2: 1441-1444. PMID: 338112
2. Miller, C.C., et al. 1988. Prostaglandins. 35: 917-938. PMID: 3141974
3. Johnson, M.M., et al. 1997. J. Nutr. 127: 1435-1444. PMID: 9237935
4. Fan, Y.Y. and Chapkin, R.S. 1998. J. Nutr. 128: 1411-1414. PMID: 9732298

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in ethanol, DMSO (~100 mg/ml), acetone, and DMF (~100 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Refractive Index :
n20D 1.48 (lit.)
IC50 :
5-LO: IC50 = 10 µM (guinea pig leukocytes)
Ki Data :
5-LO: Ki= 15 µM (rat basophilic leukemia cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5280581
MDL Number :
MFCD00065721
EC Number :
217-233-0
Beilstein Registry :
1796533
SMILES :
CCCCCC=CCC=CCC=CCCCCCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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