Molecular structure of Digoxigenin Bisdigitoxoside, CAS Number: 5297-05-2
Digoxigenin Bisdigitoxoside (CAS 5297-05-2)
Application:
Digoxigenin Bisdigitoxoside is a metabolite of Digoxin
CAS Number:
5297-05-2
Purity:
≥98%
Molecular Weight:
650.80
Molecular Formula:
C35H54O11
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Digoxigenin Bisdigitoxoside is a metabolite of Digoxin (Dx). Digoxigenin bisdigitoxoside, an exceedingly reactive compound, exhibits an affinity for binding to particular molecules within cells. Once bound, it assumes the role of a signaling agent, transmitting signals to other molecules present in the cell. This communication process, referred to as signal transduction, plays a role in the manifestation of the biochemical and physiological effects attributed to digoxigenin bisdigitoxoside.
Digoxigenin Bisdigitoxoside (CAS 5297-05-2) References
- Properties of novel anti-digoxin antisera in radioimmunoassay using homologous and site heterologous tritium-labeled antigens involving a [3H]-leucine moiety. | Ikeda, Y. and Fujii, Y. 2005. Biol Pharm Bull. 28: 340-3. PMID: 15684495
- Metabolism of digoxin, digoxigenin digitoxosides and digoxigenin in human hepatocytes and liver microsomes. | Lacarelle, B., et al. 1991. Fundam Clin Pharmacol. 5: 567-82. PMID: 1778535
- Pharmacokinetics of digoxin and main metabolites/derivatives in healthy humans. | Hinderling, PH. and Hartmann, D. 1991. Ther Drug Monit. 13: 381-401. PMID: 1957331
- Hepatic interaction between quinidine and digoxin: role of inhibition of sinusoidal Na⁺/K⁺ ATPase digoxin binding. | Li, P., et al. 2012. Eur J Pharm Sci. 47: 506-11. PMID: 22820029
- Kinetics of digoxin stability in aqueous solution. | Sternson, LA. and Shaffer, RD. 1978. J Pharm Sci. 67: 327-30. PMID: 25324
- Structural studies on the biosides of Digitalis lanata: bisdigitoxosides of digitoxigenin, gitoxigenin and digoxigenin. | Go, KT. and Bhandary, KK. 1989. Acta Crystallogr B. 45 (Pt 3): 306-12. PMID: 2619961
- Synthesis of C3-Neoglycosides of digoxigenin and their anticancer activities. | Li, XS., et al. 2018. Eur J Med Chem. 145: 252-262. PMID: 29329000
- Pharmacokinetics of digoxin in the rat. | Harrison, LI. and Gibaldi, M. 1976. Drug Metab Dispos. 4: 88-93. PMID: 3407
- Reduction of digoxin to 20R-dihydrodigoxin by cultures of Eubacterium lentum. | Robertson, LW., et al. 1986. Appl Environ Microbiol. 51: 1300-3. PMID: 3729400
- The time courses of the changes in contractile force and in transmembfane potentials induced by cardiac glycosides in guinea-pig papillary muscle. | Lüllmann, H. and Ravens, U. 1973. Br J Pharmacol. 49: 377-90. PMID: 4777701
- Variable cross-reactivity of digoxin metabolites in digoxin immunoassays. | Valdes, R., et al. 1984. Am J Clin Pathol. 82: 210-3. PMID: 6380268
- Metabolism and rate of elimination of digoxigenin bisdigitoxoside in dogs before and during chronic azotemia. | Gierke, KD., et al. 1980. J Pharmacol Exp Ther. 212: 448-51. PMID: 7359346
- Digoxin degradation in acidic dissolution medium. | Sonobe, T., et al. 1980. J Pharm Sci. 69: 410-3. PMID: 7373535
- The relationship of age to the metabolism and protein binding of digoxin in sheep. | Berman, W. and Musselman, J. 1979. J Pharmacol Exp Ther. 208: 263-6. PMID: 762659
- High-performance thin-layer chromatographic determination of digoxin and related compounds, digoxigenin bisdigitoxoside and gitoxin, in digoxin drug substance and tablets. | Ponder, GW. and Stewart, JT. 1994. J Chromatogr A. 659: 177-83. PMID: 8118558
- Specific and sensitive determination of digoxin and metabolites in human serum by high performance liquid chromatography with cyclodextrin solid-phase extraction and precolumn fluorescence derivatization. | Tzou, MC., et al. 1995. J Pharm Biomed Anal. 13: 1531-40. PMID: 8788139
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Digoxigenin Bisdigitoxoside, 2.5 mg | sc-211331 | 2.5 mg | $298.00 |