Date published: 2025-10-6

1-800-457-3801

SCBT Portrait Logo
Seach Input

Digoxigenin (CAS 1672-46-4)

0.0(0)
Write a reviewAsk a question

Alternate Names:
3β,12β,14β,21-Tetrahydroxy-20(22)-norcholenic acid lactone; 3β,12β,14-Trihydroxy-5β,20(22)-cardenolide; Lanadigigenin
Application:
Digoxigenin is a steroid used as a probe in the detection of different viruses
CAS Number:
1672-46-4
Molecular Weight:
390.51
Molecular Formula:
C23H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Digoxigenin is a steroid found in the leaves of Digitalis plants. It functions as a hapten, which can be conjugated to antibodies or nucleic acids for use in various molecular biology techniques. Its mechanism of action involves binding to antibodies or nucleic acids, allowing for the detection and visualization of specific proteins or nucleic acid sequences in cells or tissues. Digoxigenin is used in techniques such as immunohistochemistry, in situ hybridization, and blotting assays. In these applications, digoxigenin-labeled probes or antibodies bind to target molecules, enabling their detection and analysis. Digoxigenin′s ability to be conjugated to biomolecules may be versatile in studying gene expression, protein localization, and other cellular processes. Its presence can be visualized using colorimetric, chemiluminescent, or fluorescent detection methods, providing a better insights into molecular interactions and cellular functions.


Digoxigenin (CAS 1672-46-4) References

  1. Use of digoxigenin-labelled probes for the quantitation of HBV-DNA in antiviral drug evaluation.  |  Ying, C., et al. 1999. J Virol Methods. 81: 155-8. PMID: 10488773
  2. GAS CHROMATOGRAPHY OF DIGITOXIGENIN AND DIGOXIGENIN.  |  JELLIFFE, RW. and BLANKENHORN, DH. 1963. J Chromatogr. 12: 268-70. PMID: 14071804
  3. The digoxigenin:anti-digoxigenin (DIG) technology--a survey on the concept and realization of a novel bioanalytical indicator system.  |  Kessler, C. 1991. Mol Cell Probes. 5: 161-205. PMID: 1870582
  4. Digoxigenin modification of adenovirus to spatially control gene delivery from chitosan surfaces.  |  Hu, WW., et al. 2009. J Control Release. 135: 250-8. PMID: 19331850
  5. Detection of HBV-DNA using a digoxigenin-labelled probe. A rapid technique without loss of sensitivity.  |  Naoumov, NV., et al. 1991. J Hepatol. 12: 382-5. PMID: 1940269
  6. Competitive homogeneous digoxigenin immunoassay based on fluorescence quenching by gold nanoparticles.  |  Mayilo, S., et al. 2009. Anal Chim Acta. 646: 119-22. PMID: 19523564
  7. Non-radioactive labeling and detection of nucleic acids. I. A novel DNA labeling and detection system based on digoxigenin: anti-digoxigenin ELISA principle (digoxigenin system).  |  Kessler, C., et al. 1990. Biol Chem Hoppe Seyler. 371: 917-27. PMID: 2076199
  8. Magnetic trap construction.  |  Lionnet, T., et al. 2012. Cold Spring Harb Protoc. 2012: 133-8. PMID: 22194260
  9. Nonradioactive labeling of probe with digoxigenin by polymerase chain reaction.  |  Lion, T. and Haas, OA. 1990. Anal Biochem. 188: 335-7. PMID: 2221383
  10. Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity.  |  Lai, TP., et al. 2016. Biotechniques. 60: 306-9. PMID: 27286808
  11. Affinity labeling of a sulfhydryl group in the cardiacglycoside receptor site of Na+/K(+)-ATPase by N-hydroxysuccinimidyl derivatives of digoxigenin.  |  Antolovic, R., et al. 1995. Eur J Biochem. 227: 61-7. PMID: 7851443
  12. Digoxigenin-ampicillin conjugate for detection of penicillin-binding proteins by chemiluminescence.  |  Weigel, LM., et al. 1994. Antimicrob Agents Chemother. 38: 330-6. PMID: 8192459
  13. Immunological detection of glycoproteins on blots based on labeling with digoxigenin.  |  Haselbeck, A. and Hösel, W. 1993. Methods Mol Biol. 14: 161-73. PMID: 8348232
  14. Biotin and digoxigenin as labels for light and electron microscopy in situ hybridization probes: where do we stand?  |  Chevalier, J., et al. 1997. J Histochem Cytochem. 45: 481-91. PMID: 9111227
  15. Immunological detection and quantification of oxidized proteins by labelling with digoxigenin.  |  Bautista, J. and Mateos-Nevado, MD. 1998. Biosci Biotechnol Biochem. 62: 419-23. PMID: 9571770

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Digoxigenin, 25 mg

sc-214892
25 mg
$100.00

Digoxigenin, 100 mg

sc-214892A
100 mg
$160.00