Date published: 2025-9-11

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Diglyme (CAS 111-96-6)

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Alternate Names:
1,1′-Oxybis[2-methoxyethane]; Bis(2-methoxyethyl)Ether; 1,5-Dimethoxy-3-oxapentane
CAS Number:
111-96-6
Molecular Weight:
134.17
Molecular Formula:
C6H14O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diglyme is a versatile solvent known for its excellent solvating properties, particularly in both polar and non-polar solvent applications due to its ether and alcohol functional groups. Structurally, Diglyme consists of two ethylene glycol units connected by ether linkages with two terminal methyl groups, which contribute to its moderate boiling point and relatively low viscosity. In the realm of research, Diglyme is extensively utilized as a high-performance solvent in organic synthesis, where its ability to dissolve a wide range of reagents and catalysts is particularly valuable. This property facilitates various chemical reactions, including those sensitive to moisture and air. Additionally, Diglyme has been employed in the study of coordination chemistry to solvate metal ions without coordinating them, allowing researchers to isolate and study metal complexes in a relatively unaltered state. Another significant application of Diglyme is in the field of electrochemistry, where it is used as a solvent in electrolyte solutions for lithium batteries. Its robust solvating capabilities enhance the ionic conductivity of the electrolyte, thereby improving the efficiency and performance of the battery systems. Diglyme′s low toxicity compared to other glycol ethers also makes it a preferred choice in environments where safer chemical handling is prioritized.


Diglyme (CAS 111-96-6) References

  1. Subchronic inhalation toxicity of diglyme.  |  Valentine, R., et al. 1999. Food Chem Toxicol. 37: 75-86. PMID: 10069485
  2. Treatment of diglyme containing wastewater by advanced oxidation--process design and optimisation.  |  Grossmann, D., et al. 2001. Water Sci Technol. 44: 287-93. PMID: 11695472
  3. Structural and vibrational properties of diglyme and longer glymes.  |  Johansson, P., et al. 2010. J Phys Chem A. 114: 10700-5. PMID: 20828177
  4. Dynamic Diglyme-Mediated Self-Assembly of Gold Nanoclusters.  |  Compel, WS., et al. 2015. ACS Nano. 9: 11690-8. PMID: 26530638
  5. Solvation Structure of Imidazolium Cation in Mixtures of [C4mim][TFSA] Ionic Liquid and Diglyme by NMR Measurements and MD Simulations.  |  Shimomura, T., et al. 2017. J Phys Chem B. 121: 2873-2881. PMID: 28263064
  6. Effects of Diglyme on Au Nanocluster Formation: Mechanism, 1H NMR, and Bonding.  |  Wang, Y., et al. 2022. J Phys Chem A. 126: 7598-7605. PMID: 36223604
  7. Entropic Contributions to Sodium Solvation and Solvent Stabilization upon Electrochemical Sodium Deposition from Diglyme and Propylene Carbonate Electrolytes.  |  Karcher, F., et al. 2023. Angew Chem Int Ed Engl. 62: e202301253. PMID: 36924238
  8. Effect of fluoro and hydroxy analogies of diglyme on sodium-ion storage in graphite: a computational study.  |  Rathnayake, RMNM., et al. 2023. Phys Chem Chem Phys. 25: 19106-19115. PMID: 37428001
  9. Infrared Spectroscopy of Li+ Solvation in Diglyme: Ab Initio Molecular Dynamics and Experiment.  |  Yan, F., et al. 2023. J Phys Chem B. 127: 9191-9203. PMID: 37820068
  10. Developmental toxicity of diglyme by inhalation in the rat.  |  Driscoll, CD., et al. 1998. Drug Chem Toxicol. 21: 119-36. PMID: 9598295

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diglyme, 1 g

sc-211330
1 g
$260.00

Diglyme, 10 g

sc-211330A
10 g
$1600.00