Molecular structure of Digitonin, CAS Number: 11024-24-1
Digitonin (CAS 11024-24-1)
See product citations (10)
Alternate Names:
Digitonin is also known as Digitin.
Application:
Digitonin is a steroidal saponin and non-ionic biodetergent used to solubilize membrane-bound proteins.
CAS Number:
11024-24-1
Molecular Weight:
1229.31
Molecular Formula:
C56H92O29
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Digitonin, a steroidal saponin, originated from the foxglove plant Digitalis purpurea. Digitonin is a non-ionic detergent used to solubilize membrane-bound proteins. It can also water-solubilize lipids. Digitonin is often mistaken for Digoxin, or Digitoxin, all of which originate from the same foxglove plant.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Digitonin (CAS 11024-24-1) References
- Digitonin enhances the antitumor effect of cisplatin during isolated lung perfusion. | Tanaka, T., et al. 2001. Ann Thorac Surg. 72: 1173-8. PMID: 11603432
- The use of digitonin-permeabilized mammalian cells for measuring enzyme activities in the course of studies on lipid metabolism. | Geelen, MJ. 2005. Anal Biochem. 347: 1-9. PMID: 16291302
- Digitonin synergistically enhances the cytotoxicity of plant secondary metabolites in cancer cells. | Eid, SY., et al. 2012. Phytomedicine. 19: 1307-14. PMID: 23062361
- Mechanistic investigation of interactions between steroidal saponin digitonin and cell membrane models. | Frenkel, N., et al. 2014. J Phys Chem B. 118: 14632-9. PMID: 25412206
- Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol. | Sudji, IR., et al. 2015. Molecules. 20: 20146-60. PMID: 26569199
- Nuclear Protein Transport in Digitonin Permeabilized Cells. | Adam, SA. 2016. Methods Mol Biol. 1411: 479-87. PMID: 27147060
- On the Interaction between Digitonin and Cholesterol in Langmuir Monolayers. | Wojciechowski, K., et al. 2016. Langmuir. 32: 9064-73. PMID: 27518122
- Digitonin does not flip across cholesterol-poor membranes. | Fan, HY. and Heerklotz, H. 2017. J Colloid Interface Sci. 504: 283-293. PMID: 28551523
- Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin. | Malabed, R., et al. 2020. Langmuir. 36: 3600-3610. PMID: 32160747
- Digitonin concentration is determinant for mitochondrial supercomplexes analysis by BlueNative page. | Cogliati, S., et al. 2021. Biochim Biophys Acta Bioenerg. 1862: 148332. PMID: 33129827
- Digitonin derivatives of low toxicity: potential solubilizers for lipophilic compounds. | Pitha, J. and Szente, L. 1984. J Pharm Sci. 73: 240-3. PMID: 6707892
- The cytoskeleton of digitonin-treated rat hepatocytes. | Fiskum, G., et al. 1980. Proc Natl Acad Sci U S A. 77: 3430-4. PMID: 6997878
- The protective action of glycyrrhizin against saponin toxicity. | Segal, R., et al. 1977. Biochem Pharmacol. 26: 643-5. PMID: 856195
- Über Saponine Der Spirostanolreihe-Ix: Die Konstitution Des Digitonins | R. Tschesche and G. Wulff. 1963. Tetrahedron. 19: 621–634.
Activator of:
Abin-3, ATP8B, CD300E, MAP7D3, NACAD, NFAM1, NTF2, Nup160, PIG-YL, SEC24A, T1-cadherin, and TMEM16A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Digitonin, 100 mg | sc-280675A | 100 mg | $82.00 | |||
Digitonin, 250 mg | sc-280675 | 250 mg | $160.00 | |||
Digitonin, 1 g | sc-280675B | 1 g | $375.00 | |||
Digitonin, 2.5 g | sc-280675C | 2.5 g | $780.00 | |||
Digitonin, 5 g | sc-280675D | 5 g | $1450.00 | |||
Digitonin, 10 g | sc-280675E | 10 g | $2675.00 |