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Digalacturonic acid (CAS 5894-59-7)

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Alternate Names:
α-D-GalA-(1→4)-D-GalA
Application:
Digalacturonic acid is used for the co-crystallization of enzymes such as proteinase K
CAS Number:
5894-59-7
Purity:
≥85%
Molecular Weight:
370.26
Molecular Formula:
C12H18O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Digalacturonic acid, a polysaccharide formed by linking two galacturonic acid molecules through a glycosidic bond, occurs naturally in the cell walls of numerous plants and algae. Resembling the structure of cellulose, Digalacturonic acid often serves as an alternative to cellulose in various applications. In scientific research, Digalacturonic acid has undergone extensive investigation, uncovering its manifold benefits. It has been employed in the production of enzymes such as pectinase and xylanase, which aid in breaking down plant cell walls. Furthermore, Digalacturonic acid has been instrumental in the synthesis of polysaccharides like cellulose, enabling the creation of biodegradable materials. Additionally, It is used to study the transport of oligogalacturonides by systems such as the TogMNAB ABC transporter. Although the precise mechanism of action of Digalacturonic acid remains incompletely understood, it is believed to stem from its ability to bind with proteins, lipids, and carbohydrates. The highly branched structure of Digalacturonic acid facilitates interactions through multiple hydrogen bonds with other molecules.


Digalacturonic acid (CAS 5894-59-7) References

  1. Oligouronide signaling of proteinase inhibitor genes in plants: structure-activity relationships of Di- and trigalacturonic acids and their derivatives.  |  Moloshok, T., et al. 1992. Arch Biochem Biophys. 294: 731-4. PMID: 1567229
  2. Degradation of pectic substances by two pectate lyases from a human intestinal bacterium, Clostridium butyricum-beijerinckii group.  |  Nakajima, N., et al. 1999. J Biosci Bioeng. 88: 331-3. PMID: 16232622
  3. Specific recognition of saturated and 4,5-unsaturated hexuronate sugars by a periplasmic binding protein involved in pectin catabolism.  |  Abbott, DW. and Boraston, AB. 2007. J Mol Biol. 369: 759-70. PMID: 17451747
  4. High-resolution structure of proteinase K cocrystallized with digalacturonic acid.  |  Larson, SB., et al. 2009. Acta Crystallogr Sect F Struct Biol Cryst Commun. 65: 192-8. PMID: 19255463
  5. The pectinolytic enzyme of Selenomonas ruminantium.  |  Heinrichova, K., et al. 1989. J Appl Bacteriol. 66: 169-74. PMID: 2708171
  6. Metabolomics approach reveals annual metabolic variation in roots of Cyathula officinalis Kuan based on gas chromatography-mass spectrum.  |  Tong, K., et al. 2017. Chin Med. 12: 12. PMID: 28469699
  7. Immobilization of an alkaline endopolygalacturonase purified from Bacillus paralicheniformis exhibits bioscouring of cotton fabrics.  |  Khan, MM., et al. 2018. Bioprocess Biosyst Eng. 41: 1425-1436. PMID: 29926218
  8. Simulated Weightlessness Perturbs the Intestinal Metabolomic Profile of Rats.  |  Jin, M., et al. 2019. Front Physiol. 10: 1279. PMID: 31680997
  9. Biochemical Characterization of a Pectate Lyase AnPL9 from Aspergillus nidulans.  |  Suzuki, H., et al. 2022. Appl Biochem Biotechnol. 194: 5627-5643. PMID: 35802235
  10. The pectic enzymes of Aspergillus niger. A second exopolygalacturonase.  |  Mill, PJ. 1966. Biochem J. 99: 562-5. PMID: 4960793
  11. The pectic enzymes of Aspergillus niger. A mercury-activated exopolygalacturonase.  |  Mill, PJ. 1966. Biochem J. 99: 557-61. PMID: 5964957
  12. An exo-poly-alpha-D-galacturonosidase implicated in the regulation of extracellular pectate lyase production in Erwinia chrysanthemi.  |  Collmer, A., et al. 1982. J Bacteriol. 149: 626-34. PMID: 7056698
  13. Conformational study of digalacturonic acid and sodium digalacturonate in solution.  |  Gouvion, C., et al. 1994. Carbohydr Res. 261: 187-202. PMID: 7954511
  14. Uptake of galacturonic acid in Erwinia chrysanthemi EC16.  |  San Francisco, MJ. and Keenan, RW. 1993. J Bacteriol. 175: 4263-5. PMID: 8320243

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Digalacturonic acid, 10 mg

sc-214891
10 mg
$148.00

Digalacturonic acid, 25 mg

sc-214891A
25 mg
$255.00

Digalacturonic acid, 100 mg

sc-214891B
100 mg
$823.00