Date published: 2026-5-13

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Difluoroacetic acid (CAS 381-73-7)

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CAS Number:
381-73-7
Molecular Weight:
96.03
Molecular Formula:
C2H2F2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Difluoroacetic acid (DFA) is an organic acid characterized by the presence of two fluorine atoms bonded to a carboxylic acid group. It manifests as a colorless, volatile, and flammable liquid at room temperature, showcasing solubility in both water and other organic solvents. Difluoroacetic acid assumes a pivotal role in numerous scientific research applications. Primarily, it serves as a frequently employed reagent in organic synthesis, catalyzing the production of polymers and other materials. Furthermore, it acts as a substrate in metabolic studies, contributing to our understanding of biological processes. The precise mechanism of action exhibited by Difluoroacetic acid remains an area of ongoing investigation. Nevertheless, it is postulated that Difluoroacetic acid functions as an inhibitor for several enzymes, including phosphatases, proteases, and kinases. Furthermore, it has demonstrated the ability to impede the activity of several transcription factors, notably NF-κB, AP-1, and STAT3.


Difluoroacetic acid (CAS 381-73-7) References

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  2. Chromatographic efficiency and selectivity in top-down proteomics of histones.  |  Zhou, Y., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1044-1045: 47-53. PMID: 28076774
  3. Difluoroacetic Acid as a New Reagent for Direct C-H Difluoromethylation of Heteroaromatic Compounds.  |  Tung, TT., et al. 2017. Chemistry. 23: 18125-18128. PMID: 28945302
  4. Modulations of νO-H and νC═O Stretching Frequencies of Difluoroacetic Acid with Internal Rotation of CHF2 Rotor: A Combined Vapor Phase and Matrix Isolation Infrared Spectroscopy Study.  |  Bhattacharya, I., et al. 2019. J Phys Chem A. 123: 2771-2779. PMID: 30852897
  5. Evidence for the Formation of Difluoroacetic Acid in Chlorofluorocarbon-Contaminated Ground Water.  |  Dorgerloh, U., et al. 2019. Molecules. 24: PMID: 30875997
  6. Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid.  |  Meyer, CF., et al. 2019. Angew Chem Int Ed Engl. 58: 8829-8833. PMID: 31020767
  7. Nephrotoxicity of mercapturic acids of three structurally related 2,2-difluoroethylenes in the rat. Indications for different bioactivation mechanisms.  |  Commandeur, JN., et al. 1988. Biochem Pharmacol. 37: 4495-504. PMID: 3202890
  8. Effect of difluoroacetic acid and biological matrices on the development of a liquid chromatography-triple quadrupole mass spectrometry method for determination of intact growth factor proteins.  |  Maráková, K., et al. 2020. J Sep Sci. 43: 1663-1677. PMID: 32052929
  9. Effect of Brønsted Acidity on Ion Conduction in Fluorinated Acetic Acid and N-Methylimidazole Equimolar Mixtures as Pseudo-protic Ionic Liquids.  |  Watanabe, H., et al. 2020. J Phys Chem B. 124: 11157-11164. PMID: 33198463
  10. Mechanistic Investigations into and Control of Anisotropic Metal-Organic Framework Growth.  |  Bonnett, BL., et al. 2021. Inorg Chem. 60: 10439-10450. PMID: 34190552
  11. Determination, residue analysis, dietary risk assessment, and processing of flupyradifurone and its metabolites in pepper under field conditions using LC-MS/MS.  |  Feng, Y., et al. 2022. Biomed Chromatogr. 36: e5312. PMID: 34981517
  12. Efficient reductive and oxidative decomposition of haloacetic acids by the vacuum-ultraviolet/sulfite system.  |  Zhang, J., et al. 2022. Water Res. 210: 117974. PMID: 35032895
  13. Copper-Catalyzed Visible-Light-Induced Allylic Difluoromethylation of Unactivated Alkenes Using Difluoroacetic Acid.  |  Wang, J., et al. 2023. Org Lett. 25: 1045-1049. PMID: 36752311
  14. Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids.  |  Tong, Z., et al. 1998. Chem Res Toxicol. 11: 1332-8. PMID: 9815194

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Difluoroacetic acid, 5 g

sc-252718
5 g
$61.00