Molecular structure of Diflunisal, CAS Number: 22494-42-4
Diflunisal (CAS 22494-42-4)
Alternate Names:
Adomal; Fluodonil; 5-(2,4-Difluorophenyl)salicylic acid
Application:
Diflunisal is an NSAID analgesic
CAS Number:
22494-42-4
Purity:
≥98%
Molecular Weight:
250.20
Molecular Formula:
C13H8F2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diflunisal is a nonsteroidal anti-inflammatory that functions as an inhibitor of cyclooxygenase, such as COX-1 and COX-2 enzymes. It exerts its mechanism of action by irreversibly acetylating the active site of the COX enzymes, thereby prohibiting the conversion of arachidonic acid to prostaglandin H2. This inhibition leads to a decrease in the production of prostaglandins, which are involved in the inflammatory response. By reducing the levels of prostaglandins, diflunisal helps to alleviate pain, fever, and inflammation. Its mechanism of action at the molecular level involves interfering with the synthesis of prostaglandins, ultimately contributing to its anti-inflammatory and analgesic effects.
Diflunisal (CAS 22494-42-4) References
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- Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments. | Sekijima, Y. 2015. J Neurol Neurosurg Psychiatry. 86: 1036-43. PMID: 25604431
- Diflunisal inhibits prestin by chloride-dependent mechanism. | Duret, G., et al. 2017. PLoS One. 12: e0183046. PMID: 28817613
- Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents. | Abe, DO., et al. 2018. Dalton Trans. 47: 13761-13765. PMID: 30225483
- Diflunisal tolerability in transthyretin cardiac amyloidosis: a single center's experience. | Ikram, A., et al. 2018. Amyloid. 25: 197-202. PMID: 30388377
- Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway. | Yang, Y., et al. 2021. J Med Chem. 64: 797-811. PMID: 33369426
- Osteosarcoma Stem Cell Potent Gallium(III)-Polypyridyl Complexes Bearing Diflunisal. | Xiao, Z., et al. 2021. Chemistry. 27: 13846-13854. PMID: 34269487
- Diflunisal-induced neutropenia. | McLean, CA., et al. 1986. Aust N Z J Med. 16: 811-2. PMID: 3471201
- Diflunisal Targeted Delivery Systems: A Review. | Snetkov, P., et al. 2021. Materials (Basel). 14: PMID: 34772213
- Treatment With Diflunisal in Domino Liver Transplant Recipients With Acquired Amyloid Neuropathy. | Nedkova-Hristova, V., et al. 2022. Transpl Int. 35: 10454. PMID: 35497887
- Review of the animal and clinical pharmacology of diflunisal. | Davies, RO. 1983. Pharmacotherapy. 3: 9S-22S. PMID: 6344042
- Diflunisal. A new oral analgesic with an unusually long duration of action. | Forbes, JA., et al. 1982. JAMA. 248: 2139-42. PMID: 6750171
- Diflunisal: a review of its pharmacological properties and therapeutic use in pain and musculoskeletal strains and sprains and pain in osteoarthritis. | Brogden, RN., et al. 1980. Drugs. 19: 84-106. PMID: 6988202
- Diflunisal--a long-acting non-steroidal anti-inflammatory drug. A review of its pharmacology and effectiveness in management of postoperative dental pain. | Lawton, GM. and Chapman, PJ. 1993. Aust Dent J. 38: 265-71. PMID: 8216032
Inhibitor of:
Carboxylesterase (CES), SerpinA1c, SerpinA3m, and TRM12.Activator of:
γ Enolase, CRABP-II, and Ferroportin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diflunisal, 5 g | sc-205649 | 5 g | $40.00 | |||
Diflunisal, 10 g | sc-205649A | 10 g | $59.00 |