Diflubenzuron CAS: 35367-38-5
MF: C14H9ClF2N2O2
MW: 310.69
An inhibitor of TCDD-induced CYP1a1 expression in HepG2 cells.
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Diflubenzuron (CAS 35367-38-5)

Diflubenzuron | CAS 35367-38-5 is rated 5.0 out of 5 by 1.
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Application: Diflubenzuron is an inhibitor of TCDD-induced CYP1a1 expression in HepG2 cells
CAS Number: 35367-38-5
Purity: ≥96%
Molecular Weight: 310.69
Molecular Formula: C14H9ClF2N2O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

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Diflubenzuron is a benzoyl-urea insecticide, found to be a potent inhibitor of melanosome synthesis in mouse melanoma cells. Diflubenzuron has also been shown to inhibit TCDD-induced CYP1A1 expression in HepG2 cells.


References

Norman JO, Meola SM. Antimicrob Agents Ch. 23:313-6 (1983). Ledirac N, Delescluse C, Lesca P et al. Toxicol Appl Pharm. 164:273-9 (2000).

Physical State :
Solid
Solubility :
Soluble in methanol, DMSO, acetone (6.5 mg/ml at 20° C), and ethanol. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
210-232° C @95%pure
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
CCRF-CEM: IC50 >20 ug/ml (human)
pK Values :
pKa: 8.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
YS6200000
PubChem CID :
37123
Merck Index :
14: 3142
MDL Number :
MFCD00055343
EC Number :
252-529-3
Beilstein Registry :
2162461
SMILES :
C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC=C(C=C2)Cl)F

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Certificate of Analysis

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Rated 5 out of 5 by from Suman et al (PubMed ID 23860181) found that Suman et al (PubMed ID 23860181) found that the chitin synthesis inhibitor, diflubenzuron, caused changes in the egg shell morphology and abnormal egg hatching from the side of the egg wall instead of operculum of Culex mosquitoes. -SCBT Publication Review
Date published: 2015-06-23
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