Difloxacin hydrochloride (CAS 91296-86-5)
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Difloxacin is a synthetic fluoroquinolone antibiotic that functions as a bactericidal agent by inhibiting the bacterial DNA gyrase enzyme. This inhibition prevents the supercoiling of DNA, leading to the disruption of DNA replication and transcription in susceptible bacteria. Difloxacin specifically targets the A subunit of DNA gyrase, interfering with the enzyme′s ability to introduce negative supercoils into DNA. This disruption ultimately results in the accumulation of double-stranded breaks in the bacterial DNA, leading to cell death. The mechanism of action of difloxacin at the molecular level involves the formation of a stable complex with the DNA gyrase enzyme, thereby preventing the normal functioning of the enzyme in bacterial cells. This mechanism of action makes difloxacin effective against a broad spectrum of Gram-negative and Gram-positive bacteria, making it useful for studying bacterial resistance mechanisms and exploring potential strategies for combating antibiotic resistance.
Difloxacin hydrochloride (CAS 91296-86-5) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Difloxacin hydrochloride, 5 g | sc-205648 | 5 g | $190.00 | |||
Difloxacin hydrochloride, 25 g | sc-205648A | 25 g | $846.00 |