Molecular structure of DIF-3, CAS Number: 113411-17-9
DIF-3 (CAS 113411-17-9)
Alternate Names:
1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; Differentiation-inducing factor 3
CAS Number:
113411-17-9
Purity:
≥99%
Molecular Weight:
272.72
Molecular Formula:
C13H17ClO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
DIF-3 functions as a potent inhibitor of a specific enzyme involved in cellular signaling pathways. It exerts its mechanism of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting downstream signaling cascades. This disruption ultimately leads to the inhibition of certain cellular processes, making it useful for studying the molecular mechanisms underlying these pathways.
DIF-3 (CAS 113411-17-9) References
- Effects of differentiation-inducing factors of Dictyostelium discoideum on human leukemia K562 cells: DIF-3 is the most potent anti-leukemic agent. | Kubohara, Y. 1999. Eur J Pharmacol. 381: 57-62. PMID: 10528134
- Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells. | Takahashi-Yanaga, F., et al. 2003. J Biol Chem. 278: 9663-70. PMID: 12522140
- Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells. | Takahashi-Yanaga, F., et al. 2006. J Biol Chem. 281: 38489-97. PMID: 17046823
- Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo. | Nakajima-Shimada, J., et al. 2013. Biochem Pharmacol. 85: 1603-10. PMID: 23511088
- Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum [corrected]. | Kubohara, Y., et al. 2013. PLoS One. 8: e72118. PMID: 23977224
- Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum. | Kubohara, Y., et al. 2014. Biol Open. 3: 289-96. PMID: 24682009
- Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. | Kubokura, N., et al. 2015. J Pharmacol Sci. 127: 446-55. PMID: 25913757
- Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid-stimulated migration of murine osteosarcoma LM8 cells. | Kubohara, Y., et al. 2015. Biochem Biophys Res Commun. 463: 800-5. PMID: 26056940
- A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation. | Oladimeji, P., et al. 2015. Int J Cancer Clin Res. 2: 1-6. PMID: 26688830
- Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death. | Dubois, A., et al. 2016. Oncotarget. 7: 26120-36. PMID: 27027430
- Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from Dictyostelium discoideum. | Takahashi, K., et al. 2017. Biol Pharm Bull. 40: 1941-1947. PMID: 29093342
- Halogen-Substituted Derivatives of Dictyostelium Differentiation-Inducing Factor-1 Suppress Serum-Induced Cell Migration of Human Breast Cancer MDA-MB-231 Cells in Vitro. | Totsuka, K., et al. 2019. Biomolecules. 9: PMID: 31261818
- Structure elucidation of two differentiation inducing factors (DIF-2 and DIF-3) from the cellular slime mould Dictyostelium discoideum. | Morris, HR., et al. 1988. Biochem J. 249: 903-6. PMID: 3355503
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DIF-3, 1 mg | sc-257347 | 1 mg | $136.00 |