Date published: 2025-10-13

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Diethyl trimethylsilyl phosphite (CAS 13716-45-5)

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Alternate Names:
Phosphorous acid diethyl trimethylsilyl ester
Application:
Diethyl trimethylsilyl phosphite is a useful ketone synthesis reagent
CAS Number:
13716-45-5
Purity:
≥95%
Molecular Weight:
210.28
Molecular Formula:
C7H19O3PSi
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diethyl trimethylsilyl phosphite is a chemical compound employed in various research applications, particularly in the field of organophosphorus chemistry. It is often used as a reagent in the synthesis of phosphorus-containing compounds, including phosphites and phosphonates, via nucleophilic substitution reactions. The trimethylsilyl group in this compound acts as a protecting group that can be selectively removed, which is a valuable property in multi-step synthetic processes. Additionally, Diethyl trimethylsilyl phosphite is involved in the study of transition metal-catalyzed reactions, where it can act as a ligand or a reactant. Researchers also use this compound to investigate the mechanisms of phosphorylation reactions, which are fundamental in the field of biochemistry and the study of biomolecules such as nucleotides and proteins.


Diethyl trimethylsilyl phosphite (CAS 13716-45-5) References

  1. Towards the biodegradation pathway of fosfomycin.  |  Pallitsch, K., et al. 2017. Org Biomol Chem. 15: 3276-3285. PMID: 28352915
  2. Enantioselective dearomatization of isoquinolines by anion-binding catalysis en route to cyclic α-aminophosphonates.  |  Ray Choudhury, A. and Mukherjee, S. 2016. Chem Sci. 7: 6940-6945. PMID: 28626550

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diethyl trimethylsilyl phosphite, 25 ml

sc-252712
25 ml
$297.00