Date published: 2026-4-5

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Diethyl sulfate (CAS 64-67-5)

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CAS Number:
64-67-5
Molecular Weight:
154.18
Molecular Formula:
C4H10O4S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diethyl sulfate functions as an alkylating agent in research and development. It acts by transferring an ethyl group to nucleophilic amino, hydroxyl, and thiol groups in proteins and DNA. This alkylation disrupts the normal functioning of these biomolecules, leading to the inhibition of cellular processes and ultimately cell death. Diethyl sulfate′s mechanism of action involves the formation of covalent bonds with nucleophilic sites, causing structural and functional changes in the target molecules. Diethyl Sulfate′s ability to modify biomolecules at the molecular level may be a useful for studying the effects of alkylation on cellular processes and for investigating the mechanisms of DNA and protein damage. Its role in study involves elucidating the molecular consequences of alkylation and understanding the potential implications for cellular function.


Diethyl sulfate (CAS 64-67-5) References

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  2. Purpurogemutantin and purpurogemutantidin, new drimenyl cyclohexenone derivatives produced by a mutant obtained by diethyl sulfate mutagenesis of a marine-derived Penicillium purpurogenum G59.  |  Fang, SM., et al. 2012. Mar Drugs. 10: 1266-1287. PMID: 22822371
  3. Diethyl sulfate-induced cell cycle arrest and apoptosis in human bronchial epithelial 16HBE cells.  |  Zhao, P., et al. 2013. Chem Biol Interact. 205: 81-9. PMID: 23830811
  4. Enhanced arachidonic acid production from Mortierella alpina combining atmospheric and room temperature plasma (ARTP) and diethyl sulfate treatments.  |  Li, X., et al. 2015. Bioresour Technol. 177: 134-40. PMID: 25484124
  5. Enhancement of pectinase production by ultraviolet irradiation and diethyl sulfate mutagenesis of a Fusarium oxysporum isolate.  |  Yin, LB., et al. 2016. Genet Mol Res. 15: PMID: 27706785
  6. [Optimization of the method for the determination of diethyl sulfate at workplaces].  |  Kowalska, J. and Jeżewska, A. 2018. Med Pr. 69: 291-300. PMID: 29615826
  7. Two new polyketides isolated from a diethyl sulphate mutant of marine-derived Penicillium purpurogenum G59.  |  Wu, CJ., et al. 2019. Nat Prod Res. 33: 2977-2981. PMID: 30417660
  8. Engineering Corynebacterium glutamicum Mutants for 3-Methyl-1-butanol Production.  |  Zhang, Y., et al. 2019. Biochem Genet. 57: 443-454. PMID: 30644007
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  10. An association of upper respiratory cancer with exposure to diethyl sulfate.  |  Lynch, J., et al. 1979. J Occup Med. 21: 333-41. PMID: 469594
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  13. Approaches to characterize protein-DNA interactions in vivo.  |  Saluz, HP. and Jost, JP. 1993. Crit Rev Eukaryot Gene Expr. 3: 1-29. PMID: 8439708

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diethyl sulfate, 100 g

sc-239740
100 g
$48.00

Diethyl sulfate, 1 kg

sc-239740A
1 kg
$80.00