Date published: 2025-12-18

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Diethyl succinate (CAS 123-25-1)

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Alternate Names:
Succinic Acid Diethyl Ester
Application:
Diethyl succinate is a Stobbe condensation ester reagent
CAS Number:
123-25-1
Molecular Weight:
174.19
Molecular Formula:
C8H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diethyl succinate is a chemical compound that functions as a reagent in organic synthesis. It acts as an esterification agent, facilitating the formation of ester bonds in various chemical reactions. In the presence of suitable catalysts, diethyl succinate can undergo transesterification reactions, allowing for the exchange of ester groups with other compounds. Diethyl Succinate can also participate in nucleophilic substitution reactions, where the ester group is replaced by a nucleophile. Diethyl succinate can serve as a starting material for the synthesis of various intermediates and fine chemicals. Its mechanism of action involves participating in chemical reactions by providing its ester group for bonding with other molecules, thereby enabling the formation of new compounds with specific properties.


Diethyl succinate (CAS 123-25-1) References

  1. Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate.  |  Zacharias, NM., et al. 2012. J Am Chem Soc. 134: 934-43. PMID: 22146049
  2. Chemoenzymatic resolution of rac-malathion.  |  Hitt, DM., et al. 2014. Tetrahedron Asymmetry. 25: 529-533. PMID: 24839353
  3. Towards Real-time Metabolic Profiling of Cancer with Hyperpolarized Succinate.  |  Zacharias, NM., et al. 2016. J Mol Imaging Dyn. 6: PMID: 27547490
  4. RIFM fragrance ingredient safety assessment diethyl succinate, CAS Registry Number 123-25-1.  |  Api, AM., et al. 2018. Food Chem Toxicol. 115 Suppl 1: S114-S123. PMID: 29288763
  5. Flow Photochemistry as a Tool for the Total Synthesis of (+)-Epigalcatin.  |  Lisiecki, K. and Czarnocki, Z. 2018. Org Lett. 20: 605-607. PMID: 29345466
  6. Anticonvulsant activity of deaminated analogues of glutamic acid diethyl ester (GDEE).  |  Freed, WJ. and Braun, DE. 1988. Brain Res. 459: 157-62. PMID: 3167573
  7. Aroma-active compounds, sensory profile, and phenolic composition of Fondillón.  |  Issa-Issa, H., et al. 2020. Food Chem. 316: 126353. PMID: 32044705
  8. Effect of rootstocks on volatile composition of Merlot wines.  |  Carrasco-Quiroz, M., et al. 2020. J Sci Food Agric. 100: 3517-3524. PMID: 32202325
  9. Volatile Profile Characterization of Croatian Commercial Sparkling Wines.  |  Jagatić Korenika, AM., et al. 2020. Molecules. 25: PMID: 32971979
  10. Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat.  |  Swiderska, A., et al. 2021. Antioxidants (Basel). 10: PMID: 34070267
  11. Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS.  |  Wang, L., et al. 2021. Metabolites. 11: PMID: 34940612
  12. Succinate Is a Natural Suppressor of Antiviral Immune Response by Targeting MAVS.  |  Xiao, Y., et al. 2022. Front Immunol. 13: 816378. PMID: 35309330
  13. Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion.  |  Huang, LY., et al. 2023. Neural Regen Res. 18: 1040-1045. PMID: 36254990
  14. [2,5-Bis(di-propyl-amino)-4-(hy-droxy-meth-yl)phen-yl]methanol.  |  Schmitt, V., et al. 2021. IUCrdata. 6: x210443. PMID: 36339103

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diethyl succinate, 25 g

sc-234671
25 g
$53.00