Molecular structure of Diethyl Pyrocarbonate, CAS Number: 1609-47-8
Diethyl Pyrocarbonate (CAS 1609-47-8)
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Alternate Names:
Diethyl Pyrocarbonate is also known as DEPC.
Application:
Diethyl Pyrocarbonate is an inhibitor of ryanodine binding at the ryanodine/Ca2+ channel.
CAS Number:
1609-47-8
Purity:
≥97%
Molecular Weight:
162.14
Molecular Formula:
C6H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diethyl Pyrocarbonate may act to inhibit ryanodine binding to ryanodine/Ca2+ receptor channels in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. This compound could be useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Diethyl Pyrocarbonate also inhibits PAF Acetylhydrolase (platelet-activating factor acetyl hydrolase), and has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
Diethyl Pyrocarbonate (CAS 1609-47-8) References
- Diethyl pyrocarbonate inactivates CD39/ecto-ATPDase by modifying His-59. | Dzhandzhugazyan, KN. and Plesner, L. 2000. Biochim Biophys Acta. 1466: 267-77. PMID: 10825448
- Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH(3) cells. | Wu, SN. and Chang, HD. 2006. Biochem Pharmacol. 71: 615-23. PMID: 16375866
- Creating a ribonuclease-free environment. | Blumberg, DD. 1987. Methods Enzymol. 152: 20-4. PMID: 2443792
- A sensitive photoelectrochemical immunoassay of N6-methyladenosine based on dual-signal amplification strategy: Ru doped in SiO2 nanosphere and carboxylated g-C3N4. | Wang, H., et al. 2018. Biosens Bioelectron. 99: 281-288. PMID: 28779697
- Diethyl pyrocarbonate (an imidazole binding substance) inhibits rostral VLM CO2 sensitivity. | Nattie, EE. 1986. J Appl Physiol (1985). 61: 843-50. PMID: 3093453
- Copper(II) partially protects three histidine residues and the N-terminus of amyloid-β peptide from diethyl pyrocarbonate (DEPC) modification. | Friedemann, M., et al. 2020. FEBS Open Bio. 10: 1072-1081. PMID: 32255544
- Diethyl pyrocarbonate can detect a modified DNA structure induced by the binding of quinoxaline antibiotics. | Portugal, J., et al. 1988. Nucleic Acids Res. 16: 3655-70. PMID: 3287335
- Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats. | Hajipour, S., et al. 2023. Neuroscience. 519: 107-119. PMID: 36990271
- Targeted Insertion in Nicotiana benthamiana Genomes via Protoplast Regeneration. | Wu, FH., et al. 2023. Methods Mol Biol. 2653: 297-315. PMID: 36995634
- Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold. | Liu, S., et al. 2023. Sci Adv. 9: eadf5583. PMID: 37018411
- Diethyl pyrocarbonate: a chemical probe for DNA cruciforms. | Scholten, PM. and Nordheim, A. 1986. Nucleic Acids Res. 14: 3981-93. PMID: 3714469
- Diethyl pyrocarbonate: a chemical probe for secondary structure in negatively supercoiled DNA. | Herr, W. 1985. Proc Natl Acad Sci U S A. 82: 8009-13. PMID: 3865212
- Reaction of diethyl pyrocarbonate with nucleic acid components. I. Adenine. | Leonard, NJ., et al. 1970. Proc Natl Acad Sci U S A. 67: 93-8. PMID: 5272333
- Diethyl pyrocarbonate modification of the ryanodine receptor/Ca2+ channel from skeletal muscle. | Shoshan-Barmatz, V. and Weil, S. 1994. Biochem J. 299 (Pt 1): 177-81. PMID: 8166637
- Purification of RNA from animal cells using diethyl-pyrocarbonate. | Tsuei, D. and Rouhandeh, H. 1976. Experientia. 32: 749-51. PMID: 820571
- Diethyl pyrocarbonate (DEPC) inhibits CO2 chemosensitivity in Helix aspersa. | Lu, DC., et al. 1998. Respir Physiol. 111: 65-78. PMID: 9496473
Inhibitor of:
Protease, and SPDSY.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diethyl Pyrocarbonate, 5 g | sc-202574B | 5 g | $61.00 | |||
Diethyl Pyrocarbonate, 25 g | sc-202574 | 25 g | $138.00 | |||
Diethyl Pyrocarbonate, 100 g | sc-202574A | 100 g | $478.00 |