Date published: 2026-1-22

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Diethyl cyclopropane-1,1-dicarboxylate (CAS 1559-02-0)

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CAS Number:
1559-02-0
Molecular Weight:
186.21
Molecular Formula:
C9H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diethyl cyclopropane-1,1-dicarboxylate is an organophosphorus compound. This colorless and volatile liquid, characterized by a pungent odor, is the cyclic ester derived from 1,1-cyclopropanedicarboxylic acid. It exhibits solubility in various organic solvents, alcohols, and water due to its low boiling point. Diethyl cyclopropane-1,1-dicarboxylate serves as a widely utilized reagent in organic synthesis. Additionally, in vitro studies employ it to investigate the biochemical consequences of Diethyl cyclopropane-1,1-dicarboxylate on various cell types.


Diethyl cyclopropane-1,1-dicarboxylate (CAS 1559-02-0) References

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  2. Stereospecific Syntheses of Enaminonitriles and β-Enaminoesters via Domino Ring-Opening Cyclization (DROC) of Activated Cyclopropanes with Pronucleophilic Malononitriles.  |  Saha, A., et al. 2018. J Org Chem. 83: 2131-2144. PMID: 29342362
  3. Atomic physicochemical parameters for three-dimensional-structure-directed quantitative structure-activity relationships. 2. Modeling dispersive and hydrophobic interactions.  |  Ghose, AK. and Crippen, GM. 1987. J Chem Inf Comput Sci. 27: 21-35. PMID: 3558506
  4. Synthesis, crystal structure, herbicidal activity and mode of action of new cyclopropane-1,1-dicarboxylic acid analogues.  |  Min, LJ., et al. 2022. Pestic Biochem Physiol. 188: 105228. PMID: 36464348
  5. Dichloroethylaluminum-catalyzed reactions of alkenes with electrophilic cyclopropanes. A new cyclopentane annelation reaction  |  Richard B. Beal, Mark A. Dombroski, and Barry B. Snider. 1986,. J. Org. Chem. 51, 23,: 4391–4399.
  6. Ring-Opening Polymerization of Diisopropyl Cyclopropane-1,1-dicarboxylate under Living Anionic Conditions: A Kinetic and Mechanistic Study  |  Jacques Penelle and Tao Xie. 2000,. Macromolecules. 33, 13,: 4667–4672.
  7. Control of End Groups in Anionic Polymerizations Using Phosphazene Bases and Protic Precursors As Initiating System (XH-ButP4 Approach): Application to the Ring-Opening Polymerization of Cyclopropane-1,1-Dicarboxylates  |  Nicolas Illy†, Sylvie Boileau†, William Buchmann‡, Jacques Penelle†, and Valessa Barbier*†. 2010,. Macromolecules. 43, 21,: 8782–8789.
  8. Synthesis, crystal structure, bioactivity and DFT calculation of new oxime ester derivatives containing cyclopropane moiety  |  XH Liu, L Pan, CX Tan, JQ Weng, BL Wang… - Pesticide biochemistry …, 2011 - Elsevier. November 2011,. Pesticide Biochemistry and Physiology. Volume 101, Issue 3,: Pages 143-147.
  9. Synthesis and anionic ring-opening polymerization of crown-ether-like macrocyclic dilactones: An alternative route to PEG-containing polyesters and related networks  |  N Illy, E Taylan, B Brissault, J Wojno, S Boileau… - European polymer …, 2013 - Elsevier. December 2013,. European Polymer Journal. Volume 49, Issue 12,: Pages 4087-4097.
  10. Ring Opening of Donor–Acceptor Cyclopropanes with N-Nucleo­philes  |  Ekaterina M. Budynina*, et al. 2017. Synthesis;. 49(14):: 3035-3068.
  11. Rhodium Porphyrin Catalyzed Regioselective Transfer Hydrogenolysis of C–C σ-Bonds in Cyclopropanes with iPrOH  |  Chen Chen, Shiyu Feng, and Kin Shing Chan*. 2019,. Organometallics. 38, 12,: 2582–2589.
  12. Synthesis, crystal structure, herbicidal activity and mode of action of new cyclopropane-1,1-dicarboxylic acid analogues  |  LJ Min, ZH Shen, J Bajsa-Hirschel, CL Cantrell… - Pesticide Biochemistry …, 2022 - Elsevier. November 2022,. Pesticide Biochemistry and Physiology. Volume 188,: 105228.
  13. Design of Optimized Reaction Conditions for the Efficient Living Anionic Polymerization of Cyclopropane-1,1-Dicarboxylates  |   and Antoine Benlahouès, Blandine Brissault, Sylvie Boileau, Jacques Penelle. 15 December 2017. Macromolecular Chemistry and Physics. Volume219, Issue1: 1700463.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diethyl cyclopropane-1,1-dicarboxylate, 5 g

sc-252710
5 g
$112.00

Diethyl cyclopropane-1,1-dicarboxylate, 25 g

sc-252710A
25 g
$294.00