Date published: 2025-11-2

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Dienestrol (CAS 84-17-3)

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Alternate Names:
3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene
Application:
Dienestrol is A non-steroidal estrogen structurally related to stilbestrol
CAS Number:
84-17-3
Purity:
≥96%
Molecular Weight:
266.33
Molecular Formula:
C18H18O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dienestrol, a synthetic estrogen devoid of steroids, has been utilized in laboratory experiments since the 1930s. It presents itself as a white, crystalline powder, with solubility in alcohol, ether, and chloroform. By binding to the estrogen receptor and initiating its action, dienestrol triggers the activation of diverse genes and proteins. Consequently, these molecular activations bring about the physiological effects associated with estrogen in the body.


Dienestrol (CAS 84-17-3) References

  1. Hypersensitivity to diethylstilbestrol. Cross-sensitization to dienestrol, hexestrol, bisphenol A, p-benzyl-phenol, hydroquinone-monobenzylether, and p-hydroxybenzoic-benzylester.  |  FREGERT, S. and RORSMAN, H. 1960. Acta Derm Venereol. 40: 206-19. PMID: 13701662
  2. Validation of screening method for residues of diethylstilbestrol, dienestrol, hexestrol, and zeranol in bovine urine using immunoaffinity chromatography and gas chromatography/mass spectrometry.  |  Dickson, LC., et al. 2003. J AOAC Int. 86: 631-9. PMID: 14509418
  3. Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines.  |  Roner, MR., et al. 2009. BMC Cancer. 9: 358. PMID: 19811643
  4. Dienestrol; a new synthetic estrogen; its value in the menopause.  |  FINKLER, RS. and BECKER, S. 1946. J Am Med Womens Assoc. 1: 152-4. PMID: 20274062
  5. Analysis of diethylstilbestrol, dienestrol and hexestrol in biological samples by immunoaffinity extraction and gas chromatography-negative-ion chemical ionization mass spectrometry.  |  Bagnati, R., et al. 1990. J Chromatogr. 527: 267-78. PMID: 2167323
  6. Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry.  |  Xu, Q., et al. 2011. Analyst. 136: 5030-7. PMID: 21994916
  7. Packed-fiber solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products.  |  Hu, WY., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 957: 7-13. PMID: 24636894
  8. Preparation and characterization of magnetic molecularly imprinted polymers for selective trace extraction of dienestrol in seawater.  |  He, XP., et al. 2016. J Chromatogr A. 1469: 8-16. PMID: 27688174
  9. Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring.  |  Schreiber, E., et al. 2019. Food Chem Toxicol. 128: 193-201. PMID: 30986439
  10. A glassy carbon electrode modified with silver nanoparticles and functionalized multi-walled carbon nanotubes for voltammetric determination of the illicit growth promoter dienestrol in animal urine.  |  Lima Filho, MMS., et al. 2019. Mikrochim Acta. 186: 525. PMID: 31292777
  11. Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part I: Feminization effects on male rat offspring.  |  Schreiber, E., et al. 2020. Food Chem Toxicol. 139: 111256. PMID: 32171874
  12. Maternal exposure to mixtures of dienestrol, linuron and flutamide. Part II: Endocrine-related gene expression assessment on male offspring rat testes.  |  Katsanou, ES., et al. 2020. Food Chem Toxicol. 144: 111603. PMID: 32738380
  13. Gas-liquid chromatographic determination of dienestrol in the presence of methyltestosterone.  |  Fricke, FL., et al. 1968. J Pharm Sci. 57: 868-71. PMID: 5657553

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dienestrol, 100 mg

sc-239717
100 mg
$72.00