Molecular structure of Didox, CAS Number: 69839-83-4
Didox (CAS 69839-83-4)
Alternate Names:
3,4-Dihydroxybenzohydroxamic acid
Application:
Didox is a synthetic antioxidant that reduces oxidative injury levels
CAS Number:
69839-83-4
Purity:
≥98%
Molecular Weight:
169.13
Molecular Formula:
C7H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Polyhydroxylated aromatic compounds, both synthetic and natural, are important biological antioxidants. Didox is a synthetic, simple antioxidant that has been found to lower the levels of oxidative injury markers in the brains of HIV patients with dementia (1). It also increases the radiosensitivity of cancer cells by inhibiting ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis (2).
Didox (CAS 69839-83-4) References
- Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. | Inayat, MS., et al. 2002. Cancer Biol Ther. 1: 539-45. PMID: 12496485
- Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. | Turchan, J., et al. 2003. Neurology. 60: 307-14. PMID: 12552050
- Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells. | Raje, N., et al. 2006. Br J Haematol. 135: 52-61. PMID: 16925573
- Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity. | Al-Abd, AM., et al. 2013. Eur J Pharmacol. 718: 361-9. PMID: 24021537
- 3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages. | Matsebatlela, TM., et al. 2015. Chem Biol Interact. 233: 95-105. PMID: 25843059
- Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity. | Khaleel, SA., et al. 2016. Sci Rep. 6: 36855. PMID: 27841296
- Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells. | Caslin, HL., et al. 2017. Cell Immunol. 319: 10-16. PMID: 28750923
- Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription. | McLeod, JJA., et al. 2017. Cell Immunol. 322: 41-48. PMID: 28964543
- The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells. | Asperti, M., et al. 2019. Pharmaceuticals (Basel). 12: PMID: 31480699
- Didox (3,4-dihydroxybenzohydroxamic acid) reduces the vascular inflammation induced by acute intravascular hemolysis. | Silva, JAF., et al. 2020. Blood Cells Mol Dis. 81: 102404. PMID: 31972517
Inhibitor of:
Apoptosis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Didox, 1 mg | sc-221539 | 1 mg | $20.00 | |||
Didox, 5 mg | sc-221539A | 5 mg | $72.00 |