Molecular structure of Diclofenac Sodium, CAS Number: 15307-79-6
Diclofenac Sodium (CAS 15307-79-6)
See product citations (4)
Alternate Names:
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Application:
Diclofenac Sodium is an inhibitor of Cox-1 and Cox-2
CAS Number:
15307-79-6
Purity:
>99%
Molecular Weight:
318.13
Molecular Formula:
C14H10Cl2NO2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4′-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.
Diclofenac Sodium (CAS 15307-79-6) References
- Hydrolytic activity is essential for aceclofenac to inhibit cyclooxygenase in rheumatoid synovial cells. | Yamazaki, R., et al. 1999. J Pharmacol Exp Ther. 289: 676-81. PMID: 10215639
- Rational design of potent human transthyretin amyloid disease inhibitors. | Klabunde, T., et al. 2000. Nat Struct Biol. 7: 312-21. PMID: 10742177
- A comparison of gastrointestinal permeability induced by diclofenac-phospholipid complex with diclofenac acid and its sodium salt. | Khazaeinia, T. and Jamali, F. 2003. J Pharm Pharm Sci. 6: 352-9. PMID: 14738716
- Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4'-hydroxydiclofenac in rat serum. | Kaphalia, L., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 830: 231-7. PMID: 16301007
- First evidence for occurrence of hydroxylated human metabolites of diclofenac and aceclofenac in wastewater using QqLIT-MS and QqTOF-MS. | Pérez, S. and Barceló, D. 2008. Anal Chem. 80: 8135-45. PMID: 18821734
- Effect of water soluble carrier on dissolution profiles of diclofenac sodium. | Cwiertnia, B. 2013. Acta Pol Pharm. 70: 721-6. PMID: 23923395
- Degradation of diclofenac sodium using combined processes based on hydrodynamic cavitation and heterogeneous photocatalysis. | Bagal, MV. and Gogate, PR. 2014. Ultrason Sonochem. 21: 1035-43. PMID: 24262760
- Ototoxicity associated with topical administration of diclofenac sodium as an otic drop: An experimental animal study. | Acioglu, E., et al. 2017. Int J Pediatr Otorhinolaryngol. 98: 110-115. PMID: 28583486
- In Vitro Evaluation of a Foamable Microemulsion Towards an Improved Topical Delivery of Diclofenac Sodium. | Hajjar, B., et al. 2022. AAPS PharmSciTech. 23: 102. PMID: 35378669
- Formulation and Evaluation of the In Vitro Performance of Topical Dermatological Products Containing Diclofenac Sodium. | Manian, M., et al. 2022. Pharmaceutics. 14: PMID: 36145640
- Effects of Diclofenac Sodium on Seizure Activity in Rats with Pentylenetetrazole-Induced Convulsions. | Erdogan, A., et al. 2022. Neurochem Res.. PMID: 36474102
- Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. | Barnett, J., et al. 1994. Biochim Biophys Acta. 1209: 130-9. PMID: 7947975
- Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. | Laneuville, O., et al. 1994. J Pharmacol Exp Ther. 271: 927-34. PMID: 7965814
Inhibitor of:
C1s, connexin 45, Cox, Cox-2, CYP11B1, Cyp2c37, Cyp2c40, Cyp2c54, D11Wsu47e, DBX1, DDTL, EG623898, Enzyme, Igkv3-4, SAA3, and TSARG4.Activator of:
CYP2AB1, Cyp2c66, EAAT1, Glut2, and KCNT1.Substrate of:
CYP2C9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diclofenac Sodium, 5 g | sc-202136 | 5 g | $41.00 | |||
Diclofenac Sodium, 25 g | sc-202136A | 25 g | $128.00 |