Molecular structure of Dichlorvos, CAS Number: 62-73-7
Dichlorvos (CAS 62-73-7)
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Alternate Names:
Phosphoric Acid 2,2-Dichloroethenyl Dimethyl Ester; DDVP
Application:
Dichlorvos is a cholinesterase inhibitor
CAS Number:
62-73-7
Molecular Weight:
220.98
Molecular Formula:
C4H7Cl2O4P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dichlorvos is an organophosphate insecticide that functions as an acetylcholinesterase inhibitor. It acts by irreversibly binding to the active site of acetylcholinesterase, preventing the breakdown of the neurotransmitter acetylcholine. This leads to an accumulation of acetylcholine at the synaptic cleft, resulting in overstimulation of cholinergic receptors and subsequent disruption of neurotransmission. At the molecular level, dichlorvos forms a covalent bond with the serine residue at the active site of acetylcholinesterase, inhibiting its enzymatic activity. This mechanism of action ultimately leads to paralysis and death in insects.
Dichlorvos (CAS 62-73-7) References
- Dichlorvos--a comprehensive review of 11 rodent carcinogenicity studies. | Ishmael, J., et al. 2006. Regul Toxicol Pharmacol. 44: 238-48. PMID: 16439043
- Review of the in vitro and in vivo genotoxicity of dichlorvos. | Booth, ED., et al. 2007. Regul Toxicol Pharmacol. 49: 316-26. PMID: 17936460
- Dichlorvos. | . 1991. IARC Monogr Eval Carcinog Risks Hum. 53: 267-307. PMID: 1842580
- Arsenic and dichlorvos: Possible interaction between two environmental contaminants. | Flora, SJ. 2016. J Trace Elem Med Biol. 35: 43-60. PMID: 27049126
- Fatal Poisoning with Both Dichlorvos and Phenthoate. | Nara, A., et al. 2018. J Forensic Sci. 63: 1928-1931. PMID: 29601635
- Emerging Technologies for Degradation of Dichlorvos: A Review. | Zhang, Y., et al. 2021. Int J Environ Res Public Health. 18: PMID: 34071247
- Dichlorvos poisoning caused chicken cerebrum tissue damage and related apoptosis-related gene changes. | Gu, Y., et al. 2021. Sci Total Environ. 783: 147051. PMID: 34088127
- Chlorpyrifos and dichlorvos in combined exposure reveals antagonistic interaction to the freshwater fish Mrigal, Cirrhinus mrigala. | Kunwar, PS., et al. 2022. Ecotoxicology. 31: 657-666. PMID: 35298720
- Dichlorvos-induced formation of isopeptide crosslinks between proteins in SH-SY5Y cells. | Schopfer, LM. and Lockridge, O. 2022. Anal Biochem. 655: 114844. PMID: 35961399
- Effects of Dichlorvos on cardiac cells: Toxicity and molecular mechanism of action. | Ben Salem, I., et al. 2023. Chemosphere. 330: 138714. PMID: 37080471
- The chemical and biochemical reactivity of dichlorvos. | Wright, AS., et al. 1979. Arch Toxicol. 42: 1-18. PMID: 378182
- Evaluation of human health hazards on use of dichlorvos (DDVP), especially in resin strips. | Gillett, JW., et al. 1972. Residue Rev. 44: 115-59. PMID: 4576326
- Dichlorvos carcinogenicity: an assessment of the weight of experimental evidence. | Mennear, JH. 1994. Regul Toxicol Pharmacol. 20: 354-61. PMID: 7724838
Inhibitor of:
AChE, and BChE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dichlorvos, 250 mg | sc-207557 | 250 mg | $41.00 |