Molecular structure of Dichloro(1,2-diaminocyclohexane)platinum(II), CAS Number: 52691-24-4
Dichloro(1,2-diaminocyclohexane)platinum(II) (CAS 52691-24-4)
Application:
Dichloro(1,2-diaminocyclohexane)platinum(II) is an antiproliferative platinum species
CAS Number:
52691-24-4
Molecular Weight:
380.17
Molecular Formula:
C6H14Cl2N2Pt
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dichloro(1,2-diaminocyclohexane)platinum(II) is a platinum preparation that is relevant to biological studies. Dichloro(1,2-diaminocyclohexane)platinum(II) is described to be the parent complex of the Oxaliplatin (sc-202270) antiproliferative compound. One study describes block copolymer micelles prepared with Dichloro(1,2-diaminocyclohexane)platinum(II) that demonstrate release of Dichloro(1,2-diaminocyclohexane)platinum(II) in vivo to produce considerable cytotoxicity against murine colon adenocarcinoma, lower than the activity demonstrated by Oxaliplatin but increasing with exposure time as Dichloro(1,2-diaminocyclohexane)platinum(II) is slowly released by the micelles.
Dichloro(1,2-diaminocyclohexane)platinum(II) (CAS 52691-24-4) References
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- Dichloro(1,2-Diaminocyclohexane)Platinum(II) (DACHPt) Loaded Polymer Micelles with Cross-Linked Core: Preparation and Characterization. | Oberoi, HS., et al. 2011. PMSE Preprints. 104: 630-631. PMID: 25285055
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- Novel poly(2-oxazoline) block copolymer with aromatic heterocyclic side chains as a drug delivery platform. | Hwang, D., et al. 2019. J Control Release. 307: 261-271. PMID: 31260756
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- Nanoscale platform for delivery of active IRINOX to combat pancreatic cancer. | Lei, F., et al. 2021. J Control Release. 330: 1229-1243. PMID: 33217475
- Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma. | Guo, J., et al. 2021. Mol Cancer. 20: 10. PMID: 33407548
- Drug Repositioning for the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Mechanism- and Screening-Based Strategy. | Yamamoto, S. and Egashira, N. 2020. Front Pharmacol. 11: 607780. PMID: 33519471
- Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy. | Liu, X., et al. 2021. Small. 17: e2005993. PMID: 33682329
- Licochalcone B Induces ROS-Dependent Apoptosis in Oxaliplatin-Resistant Colorectal Cancer Cells via p38/JNK MAPK Signaling. | Kwak, AW., et al. 2023. Antioxidants (Basel). 12: PMID: 36978904
- Antileukemic properties of dichloro(1,2-diaminocyclohexane)platinum(II). | Gale, GR., et al. 1974. Res Commun Chem Pathol Pharmacol. 7: 529-38. PMID: 4824827
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dichloro(1,2-diaminocyclohexane)platinum(II), 500 mg | sc-239696 | 500 mg | $146.00 |