Molecular structure of Dibucaine, CAS Number: 85-79-0
Dibucaine (CAS 85-79-0)
Alternate Names:
2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide; Cinchocaine
Application:
Dibucaine is A potent long-acting local anesthetic
CAS Number:
85-79-0
Purity:
≥99%
Molecular Weight:
343.46
Molecular Formula:
C20H29N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Dibucaine is in studies related to its interaction with various biological systems, particularly its effects on nerve membrane stability and signal conduction. Some utilize Dibucaine to investigate its mechanism of action in blocking sodium channels, which provides insights into the control of neuronal excitability. Dibucaine focuses in enzymology studies where its inhibitory effects on cholinesterases are examined. Understanding these interactions helps identify the pathways through which nerve signals are moderated. Dibucaine is also in the study of lipid bilayers, where it serves as a probe to understand the impacts of anesthetics on cellular membranes.
Dibucaine (CAS 85-79-0) References
- Dibucaine-induced modification of sodium transport in toad skin and of model membrane structures. | Suwalsky, M., et al. 2001. Z Naturforsch C J Biosci. 56: 614-22. PMID: 11531098
- Dibucaine elicits platelet procoagulant activity in factor VIII and factor X activation by a mechanism involving a sulfhydryl-dependent enzyme. | Hultin, MB., et al. 1992. Thromb Res. 68: 399-407. PMID: 1290168
- The use of monolayers for simple and quantitative analysis of lipid-drug interactions exemplified with dibucaine and substance P. | Seelig, A. 1990. Cell Biol Int Rep. 14: 369-80. PMID: 1693884
- Simultaneous determination of dibucaine and naphazoline in human serum by monolithic silica spin column extraction and liquid chromatography-mass spectrometry. | Saito, T., et al. 2008. J Chromatogr B Analyt Technol Biomed Life Sci. 872: 186-90. PMID: 18657485
- Dibucaine toxicosis in a dog. | Hanzlicek, AS. and Van der Merwe, D. 2010. J Med Toxicol. 6: 44-9. PMID: 20224995
- Cellular responses associated with dibucaine-induced phospholipidosis. | Peropadre, A., et al. 2011. Chem Res Toxicol. 24: 185-92. PMID: 21261262
- Potent inhibition of anoxic depolarization by the sodium channel blocker dibucaine. | Douglas, HA., et al. 2011. J Neurophysiol. 105: 1482-94. PMID: 21273307
- Selective effect of procaine, tetracaine and dibucaine on gold nanoparticles. | Mocanu, A., et al. 2012. J Nanosci Nanotechnol. 12: 8935-9. PMID: 23447941
- Dibucaine in Ionic-Gradient Liposomes: Biophysical, Toxicological, and Activity Characterization. | Couto, VM., et al. 2018. J Pharm Sci. 107: 2411-2419. PMID: 29802933
- Cardiolipin and phosphatidylethanolamine role in dibucaine interaction with the mitochondrial membrane. | Lopes, SC., et al. 2019. Biochim Biophys Acta Biomembr. 1861: 1152-1161. PMID: 30840858
- Pre-clinical evaluation of new dibucaine formulations for preventive analgesia. | Furlan, B., et al. 2021. J Liposome Res. 31: 230-236. PMID: 32567452
- Dibucaine-induced synchronous mucocyst secretion in Tetrahymena. | Satir, B. 1977. Cell Biol Int Rep. 1: 69-73. PMID: 610868
- Dibucaine interacts differently with membrane and protein in cytochrome c oxidase systems. | He, J. and Nicholls, P. 1993. Biochem Cell Biol. 71: 14-21. PMID: 8392353
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dibucaine, 5 g | sc-252684 | 5 g | $92.00 |