Dibenzyl N,N-Diisopropylphosphoramidite (CAS 108549-23-1)
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Dibenzyl N,N-Diisopropylphosphoramidite is a chemical reagent used extensively in the synthesis of oligonucleotides. In research focused on genetics and molecular biology, this compound is pivotal for the automated solid-phase synthesis of DNA sequences. It acts as a phosphitylating agent that facilitates the coupling of nucleoside residues to the growing oligonucleotide chain under controlled conditions. The dibenzyl and diisopropyl groups in the molecule provide stability to the phosphorous center, while allowing for subsequent oxidation to form the necessary phosphate linkages in the DNA backbone. Researchers also employ dibenzyl N,N-Diisopropylphosphoramidite to study the effects of various modifications on the stability and function of synthetic nucleic acids.
Dibenzyl N,N-Diisopropylphosphoramidite (CAS 108549-23-1) References
- Chemical synthesis and in vitro biological evaluation of a phosphorylated bisubstrate inhibitor of type 3 17beta-hydroxysteroid dehydrogenase. | Bérubé, M. and Poirier, D. 2007. J Enzyme Inhib Med Chem. 22: 201-11. PMID: 17518347
- An investigation of the reactions between azido alcohols and phosphoramidites. | Wu, J., et al. 2019. Synlett. 30: 348-352. PMID: 31772422
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dibenzyl N,N-Diisopropylphosphoramidite, 1 g | sc-211298B | 1 g | $67.00 | |||
Dibenzyl N,N-Diisopropylphosphoramidite, 5 g | sc-211298 | 5 g | $141.00 | |||
Dibenzyl N,N-Diisopropylphosphoramidite, 25 g | sc-211298A | 25 g | $525.00 | |||
Dibenzyl N,N-Diisopropylphosphoramidite, 100 g | sc-211298C | 100 g | $1504.00 | |||
Dibenzyl N,N-Diisopropylphosphoramidite, 250 g | sc-211298D | 250 g | $3069.00 | |||
Dibenzyl N,N-Diisopropylphosphoramidite, 1 kg | sc-211298E | 1 kg | $6143.00 | |||
Dibenzyl N,N-Diisopropylphosphoramidite, 5 kg | sc-211298F | 5 kg | $27417.00 |