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Dibenzo[e,l]pyrene (CAS 192-51-8)

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Alternate Names:
Dibenzo[fg,op]naphthacene; 1,2:6,7-Dibenzpyrene; NSC 87522
CAS Number:
192-51-8
Molecular Weight:
302.37
Molecular Formula:
C24H14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dibenzo[e,l]pyrene is a polycyclic aromatic hydrocarbon (PAH) with a structure that includes five fused benzene rings, placing it among the higher molecular weight PAHs. It is often the subject of environmental and chemical research due to its properties and presence in the products of incomplete combustion. In research applications, Dibenzo[e,l]pyrene is frequently used to investigate the environmental fate, transport, and transformation of PAHs, as it can be a marker for the efficiency of combustion processes and the presence of high-temperature pyrolysis. Its high molecular weight and structure also make it an ideal candidate for studies on the mutagenic and carcinogenic potentials of PAHs, contributing to the field of toxicology and environmental health. Additionally, Dibenzo[e,l]pyrene is used in the development and calibration of analytical methods, such as gas chromatography and mass spectrometry, to detect and quantify PAHs in environmental samples, providing valuable data on pollution and its impacts on ecosystems and human health.


Dibenzo[e,l]pyrene (CAS 192-51-8) References

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  2. Inhibition of dibenzo[a,l]pyrene-induced multi-organ carcinogenesis by dietary chlorophyllin in rainbow trout.  |  Reddy, AP., et al. 1999. Carcinogenesis. 20: 1919-26. PMID: 10506105
  3. Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation.  |  Buters, JT., et al. 2002. Chem Res Toxicol. 15: 1127-35. PMID: 12230405
  4. Dibenzo[A,L]pyrene-induced genotoxic and carcinogenic responses are dramatically suppressed in aryl hydrocarbon receptor-deficient mice.  |  Nakatsuru, Y., et al. 2004. Int J Cancer. 112: 179-83. PMID: 15352028
  5. Metabolism and mutagenicity of dibenzo[a,e]pyrene and the very potent environmental carcinogen dibenzo[a,l]pyrene.  |  Devanesan, PD., et al. 1990. Chem Res Toxicol. 3: 580-6. PMID: 2103330
  6. Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS.  |  Zhang, SM., et al. 2011. Chem Res Toxicol. 24: 1297-303. PMID: 21736370
  7. Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent.  |  Chen, KM., et al. 2013. Int J Cancer. 133: 1300-9. PMID: 23483552
  8. Simultaneous detection of deoxyadenosine and deoxyguanosine adducts in the tongue and other oral tissues of mice treated with Dibenzo[a,l]pyrene.  |  Zhang, SM., et al. 2014. Chem Res Toxicol. 27: 1199-206. PMID: 24911113
  9. Effect of phytochemical intervention on dibenzo[a,l]pyrene-induced DNA adduct formation.  |  Russell, GK., et al. 2015. Mutat Res. 774: 25-32. PMID: 25794985
  10. Structural Insight into the Mechanism of Dibenzo[a,l]pyrene and Benzo[a]pyrene-Mediated Cell Proliferation Using Molecular Docking Simulations.  |  Khan, MKA., et al. 2018. Interdiscip Sci. 10: 653-673. PMID: 28374118
  11. Stereoselective activation of dibenzo[a,l]pyrene to (-)-anti (11R,12S,13S,14R)- and (+)-syn(11S,12R,13S,14R)-11,12-diol-13,14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.  |  Ralston, SL., et al. 1995. Carcinogenesis. 16: 2899-907. PMID: 8603462
  12. Dibenzo[a,l]pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung.  |  Prahalad, AK., et al. 1997. Carcinogenesis. 18: 1955-63. PMID: 9364006
  13. Dibenzo[a,l]pyrene (dibenzo[def,p]chrysene): fjord-region distortions.  |  Katz, AK., et al. 1998. Carcinogenesis. 19: 1641-8. PMID: 9771936

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dibenzo[e,l]pyrene, 10 mg

sc-499956
10 mg
$402.00