Date published: 2026-2-12

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Diammonium glycyrrhizinate (CAS 79165-06-3)

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CAS Number:
79165-06-3
Molecular Weight:
856.99
Molecular Formula:
C42H68N2O16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diammonium glycyrrhizinate is a salt derived from glycyrrhizic acid, a principal compound found in the roots of Glycyrrhiza glabra, known as licorice. In the realm of research, particularly in biochemistry and molecular biology, diammonium glycyrrhizinate serves as useful due to its unique properties and mechanisms of action. Its primary mechanism involves the modulation of certain signaling pathways and the inhibition of enzyme activities that are in the study of cellular processes and inflammatory responses. For instance, it has been extensively used in studies focusing on the regulation of immune responses, where its ability to influence the activity of enzymes such as 11β-hydroxysteroid dehydrogenase, which plays a pivotal role in cortisol metabolism, is of particular interest. Additionally, its anti-inflammatory properties, attributed to the inhibition of enzymes like cyclooxygenase and lipoxygenase, make it a compound of choice for investigating the underlying mechanisms of inflammation and for exploring potential anti-inflammatory strategies in various models of cellular and molecular research. This compound′s unique attributes facilitate a deeper understanding of the intricate interplay between biochemical pathways and offer a window into the modulation of cellular functions, making it an indispensable asset in scientific investigations that aim to unravel the complexities of biological systems.


Diammonium glycyrrhizinate (CAS 79165-06-3) References

  1. Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism.  |  Chen, L., et al. 2009. Xenobiotica. 39: 955-63. PMID: 19831503
  2. Diammonium glycyrrhizinate upregulates PGC-1α and protects against Aβ1-42-induced neurotoxicity.  |  Zhu, X., et al. 2012. PLoS One. 7: e35823. PMID: 22540007
  3. Diammonium glycyrrhizinate attenuates Aβ(1-42) -induced neuroinflammation and regulates MAPK and NF-κB pathways in vitro and in vivo.  |  Zhao, H., et al. 2013. CNS Neurosci Ther. 19: 117-24. PMID: 23279783
  4. Effect of diammonium glycyrrhizinate on entecavir pharmacokinetics in rats.  |  Li, FY., et al. 2013. Chin J Nat Med. 11: 309-13. PMID: 23725847
  5. Diammonium glycyrrhizinate alleviates hepatopulmonary syndrome via restoring superoxide dismutase 3 activity in rats.  |  Zhao, X., et al. 2017. Eur J Pharmacol. 807: 144-150. PMID: 28435094
  6. The synergy of diammonium glycyrrhizinate remarkably reduces the toxicity of oxymatrine in ICR mice.  |  Shi, HJ., et al. 2018. Biomed Pharmacother. 97: 19-25. PMID: 29080454
  7. Diammonium Glycyrrhizinate Protects against Nonalcoholic Fatty Liver Disease in Mice through Modulation of Gut Microbiota and Restoration of Intestinal Barrier.  |  Li, Y., et al. 2018. Mol Pharm. 15: 3860-3870. PMID: 30036479
  8. Effect of diammonium glycyrrhizinate on pharmacokinetics of omeprazole by regulating cytochrome P450 enzymes and plasma protein binding rate.  |  Han, L., et al. 2019. Xenobiotica. 49: 975-980. PMID: 30215539
  9. Combination of oxymatrine and diammonium glycyrrhizinate significantly mitigates mice allergic contact dermatitis induced by dinitrofluorobenzene.  |  Shi, HJ., et al. 2019. Exp Biol Med (Maywood). 244: 1111-1119. PMID: 31342769
  10. Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs.  |  Gao, M., et al. 2019. Drug Des Devel Ther. 13: 3579-3589. PMID: 31802846
  11. In Silico Analysis Identifies the Anti-Liver Injury Targets of Diammonium Glycyrrhizinate: Validated in Perfluorooctanoic Acid-Lesioned Mouse Model.  |  Qin, J., et al. 2022. Chem Biodivers. 19: e202100938. PMID: 35362201
  12. Diammonium Glycyrrhizinate Preparation for Liver Function Recovery in Chronic Hepatitis B in China: A Meta-analysis with Trial Sequential Analysis.  |  Liu, Y., et al. 2022. Curr Pharm Des. 28: 2089-2112. PMID: 35593360
  13. Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3.  |  Zhao, X., et al. 2022. Eur J Pharmacol. 929: 175115. PMID: 35738453
  14. [Effects and mechanism of diammonium glycyrrhizinate on liver injury in severely scalded rats].  |  Xie, CQ., et al. 2022. Zhonghua Shao Shang Za Zhi. 38: 735-743. PMID: 36058696
  15. Efficacy of diammonium glycyrrhizinate in the treatment of rosacea with papules and pustules: A randomized, double-blind, placebo-controlled study.  |  Xie, Y., et al. 2022. Dermatol Ther. 35: e15905. PMID: 36200523

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diammonium glycyrrhizinate, 25 mg

sc-492097
25 mg
$158.00