Molecular structure of Diamide, CAS Number: 10465-78-8
Diamide (CAS 10465-78-8)
See product citations (5)
Alternate Names:
1,1′-Azobis(N,N-dimethylformamide); N,N,N′,N′-Tetramethylazodicarboxamide; Azodicarboxylic acid bis(dimethylamide); Diazenedicarboxylic acid bis(N,N-dimethylamide); TMAD
Application:
Diamide is a reagent used as a thiol oxidizing agent
CAS Number:
10465-78-8
Purity:
≥96%
Molecular Weight:
172.19
Molecular Formula:
C6H12N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diamide is of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Diamide is classified as a monoazo compound and acts as a sulfhydryl reagent that facilitates the oxidation of sulfhydryl groups into disulfide form. This compound exhibits radiation-sensitizing properties, particularly in anoxic bacterial and mammalian cells.
Diamide (CAS 10465-78-8) References
- Diamide induces reversible changes in morphology, cytoskeleton and cell-cell coupling in lens epithelial cells. | Prescott, AR., et al. 1991. Exp Eye Res. 52: 83-92. PMID: 1868889
- Diamide: positive inotropic effect in isolated atria and inhibition of Na+/Ca2+ exchange in cardiomyocytes. | Antolini, M., et al. 1991. Pharmacol Res. 23: 163-72. PMID: 2062792
- Diamide-induced cross-linking of the lens water-soluble proteins as a model of the early oxidative changes during senile cataract formation. | Babizhayev, MA. and Menshikova, EV. 1990. Mech Ageing Dev. 56: 199-208. PMID: 2089197
- Diamide induced shift in protein and glutathione thiol: disulfide status delays DNA rejoining after X-irradiation of human cancer cells. | Baker, MA. and Hagner, BA. 1990. Biochim Biophys Acta. 1037: 39-47. PMID: 2294969
- Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors. | Nakajima, K., et al. 2016. Bioorg Med Chem Lett. 26: 1245-8. PMID: 26804232
- Diamide: mechanisms of action and interactions with other sensitizers. | Harris, JW. and Power, JA. 1978. Br J Cancer Suppl. 3: 84-9. PMID: 277263
- Seeded Polymerization through the Interplay of Folding and Aggregation of an Amino-Acid-based Diamide. | Ogi, S., et al. 2018. Angew Chem Int Ed Engl. 57: 2339-2343. PMID: 29336518
- Contrasting susceptibility of lepidopteran pests to diamide and pyrethroid insecticides in a region of overwintering and migratory intersection. | Rabelo, MM., et al. 2020. Pest Manag Sci. 76: 4240-4247. PMID: 32614113
- Varying contributions of three ryanodine receptor point mutations to diamide insecticide resistance in Plutella xylostella. | Jiang, D., et al. 2021. Pest Manag Sci. 77: 4874-4883. PMID: 34176224
- A haploid diamondback moth (Plutella xylostella L.) genome assembly resolves 31 chromosomes and identifies a diamide resistance mutation. | Ward, CM., et al. 2021. Insect Biochem Mol Biol. 138: 103622. PMID: 34252570
- A Target Site Mutation Associated With Diamide Insecticide Resistance in the Diamondback Moth Plutella xylostella (Lepidoptera: Plutellidae) is Widespread in South Georgia and Florida Populations. | Dunn, TP'., et al. 2022. J Econ Entomol. 115: 289-296. PMID: 34850042
- The effect of oxidant stress on diamide-treated human granulocytes. | Weiss, SJ. and Sagone, AL. 1979. Biochim Biophys Acta. 585: 620-9. PMID: 465544
- The reduction of diamide by rat liver mitochondria and the role of glutathione. | Jocelyn, PC. 1978. Biochem J. 176: 649-64. PMID: 747642
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diamide, 1 g | sc-211289 | 1 g | $153.00 | |||
Diamide, 5 g | sc-211289A | 5 g | $582.00 |