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Di-n-octyl phthalate (CAS 117-84-0)

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Alternate Names:
DNOP; Phthalic acid di-n-octyl ester
CAS Number:
117-84-0
Molecular Weight:
390.56
Molecular Formula:
C24H38O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Di-n-octyl phthalate, categorized as a plasticizer, is found widely in the environment. It is used in the production of flooring tiles, bottle cap liners, toys, and even indirect food addititives. Di-n-octyl phthalate is a phthalate as a plasticizer in polyvinyl chloride and used as an analytical reagent for determining activated phthalates in water, food, and human serum samples. Studies show that di-n-octyl phthalate can inhibit mitochondrial function and cellular respiration. Additionally, it has shown to blocking protein synthesis, resulting in the inhibition of bacterial growth, as seen with Escherichia coli.


Di-n-octyl phthalate (CAS 117-84-0) References

  1. NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate.  |  Kavlock, R., et al. 2002. Reprod Toxicol. 16: 721-34. PMID: 12406498
  2. Urinary metabolites of di-n-octyl phthalate in rats.  |  Silva, MJ., et al. 2005. Toxicology. 210: 123-33. PMID: 15840426
  3. Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate.  |  Calafat, AM., et al. 2006. J Toxicol Environ Health A. 69: 215-27. PMID: 16263692
  4. Prenatal developmental toxicity studies on di-n-heptyl and di-n-octyl phthalates in Sprague-Dawley rats.  |  Saillenfait, AM., et al. 2011. Reprod Toxicol. 32: 268-76. PMID: 21907788
  5. Complete degradation of di-n-octyl phthalate by Gordonia sp. strain Dop5.  |  Sarkar, J., et al. 2013. Chemosphere. 90: 2571-7. PMID: 23211327
  6. Biochemical pathways and enhanced degradation of di-n-octyl phthalate (DOP) in sequencing batch reactor (SBR) by Arthrobacter sp. SLG-4 and Rhodococcus sp. SLG-6 isolated from activated sludge.  |  Zhang, K., et al. 2018. Biodegradation. 29: 171-185. PMID: 29450665
  7. Di-n-octyl phthalate degradation by a halotolerant bacterial consortium LF and its application in soil.  |  Wang, Y., et al. 2021. Environ Technol. 42: 2749-2756. PMID: 31961776
  8. Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function in male rats.  |  Zhu, X., et al. 2021. Ecotoxicol Environ Saf. 208: 111432. PMID: 33075588
  9. Biodegradation of di-n-octyl phthalate by Gordonia sp. Lff and its application in soil.  |  Wang, Y., et al. 2022. Environ Technol. 43: 2604-2611. PMID: 33577396
  10. Development of ecological risk assessment for Diisobutyl phthalate and di-n-octyl phthalate in surface water of China based on species sensitivity distribution model.  |  Huan-Yu, T., et al. 2022. Chemosphere. 307: 135932. PMID: 35940414
  11. Effect of di-n-octyl phthalate on fatty acid composition of phosphatidylcholine in Tetrahymena.  |  Kaya, K. and Nohara, K. 1987. Chem Biol Interact. 64: 93-101. PMID: 3690725
  12. Comparison of the short-term effects of di(2-ethylhexyl) phthalate, di(n-hexyl) phthalate, and di(n-octyl) phthalate in rats.  |  Mann, AH., et al. 1985. Toxicol Appl Pharmacol. 77: 116-32. PMID: 3966235
  13. Comparative studies of the hepatic effects of di- and mono-n-octyl phthalates, di-(2-ethylhexyl) phthalate and clofibrate in the rat.  |  Lake, BG., et al. 1984. Acta Pharmacol Toxicol (Copenh). 54: 167-76. PMID: 6720315
  14. Subchronic oral toxicity of di-n-octyl phthalate and di(2-Ethylhexyl) phthalate in the rat.  |  Poon, R., et al. 1997. Food Chem Toxicol. 35: 225-39. PMID: 9146736

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Di-n-octyl phthalate, 1 g

sc-257308
1 g
$59.00

Di-n-octyl phthalate, 10 g

sc-257308A
10 g
$255.00

Di-n-octyl phthalate, 50 g

sc-257308B
50 g
$561.00