Molecular structure of DH 97, CAS Number: 343263-95-6
DH 97 (CAS 343263-95-6)
Application:
DH 97 is a MEL-1B-R (melatonin receptor )antagonist
CAS Number:
343263-95-6
Molecular Weight:
334.46
Molecular Formula:
C22H26N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
DH 97 is a MEL-1B-R (melatonin receptor) antagonist (pKi value = 8.03). DH 97 exhibits 89 times more selectivity than MEL-1A-R and is 229 times more selective than GPR50.
DH 97 (CAS 343263-95-6) References
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- Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. | Sjöblom, M., et al. 2003. Am J Physiol Gastrointest Liver Physiol. 284: G1034-44. PMID: 12584110
- Characterization of CHO cells stably expressing a G alpha 16/z chimera for high throughput screening of GPCRs. | New, DC. and Wong, YH. 2004. Assay Drug Dev Technol. 2: 269-80. PMID: 15285908
- Melatonin-enhanced hyperactivation of hamster sperm. | Fujinoki, M. 2008. Reproduction. 136: 533-41. PMID: 18715981
- MT2-like melatonin receptor modulates amplitude receptor potential in visual cells of crayfish during a 24-hour cycle. | Mendoza-Vargas, L., et al. 2009. Comp Biochem Physiol A Mol Integr Physiol. 154: 486-92. PMID: 19666131
- International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. | Dubocovich, ML., et al. 2010. Pharmacol Rev. 62: 343-80. PMID: 20605968
- Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. | Kojima, S., et al. 2011. Br J Pharmacol. 162: 1179-85. PMID: 21091649
- Design of novel melatonin analogs for the reduction of intraocular pressure in normotensive rabbits. | Alarma-Estrany, P., et al. 2011. J Pharmacol Exp Ther. 337: 703-9. PMID: 21368006
- Melatonin membrane receptors in peripheral tissues: distribution and functions. | Slominski, RM., et al. 2012. Mol Cell Endocrinol. 351: 152-66. PMID: 22245784
- Melatonin receptors trigger cAMP production and inhibit chloride movements in nonpigmented ciliary epithelial cells. | Huete-Toral, F., et al. 2015. J Pharmacol Exp Ther. 352: 119-28. PMID: 25344385
- Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. | Teh, MT. and Sugden, D. 1998. Naunyn Schmiedebergs Arch Pharmacol. 358: 522-8. PMID: 9840420
- Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa | Kojima, S. I., Tohei, A., & Ikeda, M. 2011. British journal of pharmacology. 162(5): 1179-1185.
Inhibitor of:
MEL-1B-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DH 97, 10 mg | sc-205941 | 10 mg | $135.00 | |||
DH 97, 50 mg | sc-205941A | 50 mg | $547.00 |