Dextromethorphan Hydrobromide (CAS 125-69-9)

Dextromethorphan hydrobromide, a synthetic derivative of morphine, is extensively utilized in research laboratories, primarily for its neuropharmacological properties. In the realm of neuroscientific research, it serves as useful for studying NMDA (N-methyl-D-aspartate) receptors, a class of receptors that play a role in synaptic plasticity, memory function, and neurodevelopment. By acting as an antagonist at these receptors, dextromethorphan hydrobromide helps researchers understand the mechanisms of diseases like Alzheimer′s and Parkinson′s, where NMDA receptor dysfunction is implicated. Additionally, its sigma-1 receptor agonist activity makes it useful in investigating the role of these receptors in neuroprotection, neuroplasticity, and mood regulation. This chemical is also employed in studies exploring cough reflex pathways, aiding in the understanding of the central processing of cough reflexes. Moreover, its application extends to research in drug abuse and addiction, offering insights into the neurochemical pathways involved in substance dependency. In psychopharmacological studies, dextromethorphan hydrobromide is used to simulate certain aspects of psychosis, thereby enabling the exploration of potential antipsychotic treatments. Furthermore, its impact on glutamate neurotransmission is a subject of investigation in studies related to excitotoxicity and neurodegenerative disorders. Overall, dextromethorphan hydrobromide′s multifaceted pharmacological profile renders it a versatile agent in neuroscience and pharmacology research, providing a deeper understanding of various neurobiological processes and pathologies.