Dexmedetomidine hydrochloride CAS: 145108-58-3
MF: C13H16N2 HCl
MW: 236.74
An active isomer of medetomide, a potent and highly selective α2-adrenoceptor agonist.

Dexmedetomidine hydrochloride (CAS 145108-58-3)

Dexmedetomidine hydrochloride | CAS 145108-58-3 is rated 5.0 out of 5 by 1.
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Alternate Names: d-Medetomidine hydrochloride
Application: Dexmedetomidine hydrochloride is an active isomer of medetomide, a potent and highly selective α2-adrenoceptor agonist
CAS Number: 145108-58-3
Purity: ≥98%
Molecular Weight: 236.74
Molecular Formula: C13H16N2 HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Dexmedetomidine hydrochloride is the active isomer of medetomide which acts a potent, highly selective α2-AR (α2-adrenoceptor) agonist.


References

Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9. Scheinin et al (1989) Medetomidine - a novel a2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635. Fisher et al (1991) Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur.J.Pharmacol. 192 221.

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM), DMSO (48 mg/ml), and ethanol (48 mg/ml).
Storage :
Desiccate at room temperature
Boiling Point :
381.9° C at 760 mmHg (Predicted)
Density :
1.17 g/cm3
Refractive Index :
n20D 1.57 (Predicted)
Optical Activity :
α20/D +51.4°, c = 1 in water
IC50 :
α2A-AR: EC5050 = 1.5 nM (human)
Ki Data :
α1D-AR: Ki= 0.015 nM (human); α-2a adrenergic receptor: Ki= 0.015 nM (rat); α2-AR: Ki= 1.08 nM; Adrenergic receptor α-1: Ki= 5 nM (rat); α1-AR: Ki= 1750 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
NI5156750
PubChem CID :
6918081
MDL Number :
MFCD07772269
Beilstein Registry :
8937629
SMILES :
CC1=C(C(=CC=C1)[[email protected]](C)C2=CN=CN2)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Dexmedetomidine hydrochloride, sc-202290, is a white or off-white crystalline powder.
Answered by: TechService7
Date published: 2017-01-27
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Rated 5 out of 5 by from Uskur et al Uskur et al. (PubMed ID 26376284) found that Dexmedetomidine hydrochloride induced conditioned place preference, similar to that caused by morphine, in rats. -SCBT Publication Review
Date published: 2015-06-07
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