Dexmedetomidine hydrochloride is the active isomer of medetomide which acts a potent, highly selective α2-AR (α2-adrenoceptor) agonist.
Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9. Scheinin et al (1989) Medetomidine - a novel a2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635. Fisher et al (1991) Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur.J.Pharmacol. 192 221.
Soluble in water (100 mM), DMSO (48 mg/ml), and ethanol (48 mg/ml).
Rated 5 out of
Uskur et alUskur et al. (PubMed ID 26376284) found that Dexmedetomidine hydrochloride induced conditioned place preference, similar to that caused by morphine, in rats. -SCBT Publication Review
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