Molecular structure of Dexmedetomidine hydrochloride, CAS Number: 145108-58-3
Dexmedetomidine hydrochloride (CAS 145108-58-3)
Alternate Names:
d-Medetomidine hydrochloride
Application:
Dexmedetomidine hydrochloride is an active isomer of medetomide, a potent and highly selective α2-adrenoceptor agonist
CAS Number:
145108-58-3
Purity:
≥98%
Molecular Weight:
236.74
Molecular Formula:
C13H16N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dexmedetomidine hydrochloride is extensively utilized in research focusing on its mechanisms of action on alpha-2 adrenoceptors. This compound is pivotal in studies evaluating how selective agonism at these receptors affects neurotransmitter release in the central nervous system. Researchers employ Dexmedetomidine hydrochloride to explore its role in modulating synaptic transmission, which provides insights into the regulation of sedation and anxiolysis at a molecular level. Additionally, it is used in studies to investigate potential effects on cognitive functions and memory. Dexmedetomidine hydrochloride also serves as a tool in physiological research, particularly in understanding the responses of cardiovascular systems to alpha-2 adrenergic stimulation.
Dexmedetomidine hydrochloride (CAS 145108-58-3) References
- Effect of dexmedetomidine pretreatment on lung injury following intestinal ischemia-reperfusion. | Shen, J., et al. 2013. Exp Ther Med. 6: 1359-1364. PMID: 24255662
- Fear conditioning potentiates synaptic transmission onto long-range projection neurons in the lateral subdivision of central amygdala. | Penzo, MA., et al. 2014. J Neurosci. 34: 2432-7. PMID: 24523533
- Effects of Dexmedetomidine combined with Dezocine on cognition function and hippocampal microglia activation of rats. | Wan, Q., et al. 2014. Int J Clin Exp Med. 7: 2787-92. PMID: 25356140
- Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain: Role of interleukin-6 and tumor necrosis factor-α. | Farghaly, HS., et al. 2016. Eur J Pharmacol. 776: 139-45. PMID: 26896779
- Mesenchymal Stem Cell-Derived Exosomes: Immunomodulatory Evaluation in an Antigen-Induced Synovitis Porcine Model. | Casado, JG., et al. 2017. Front Vet Sci. 4: 39. PMID: 28377922
- Evaluation of antigen-induced synovitis in a porcine model: Immunological, arthroscopic and kinetic studies. | Vela, FJ., et al. 2017. BMC Vet Res. 13: 93. PMID: 28388908
- Immunomodulatory Effects of Fentanyl or Dexmedetomidine Hydrochloride Infusion After Allogeneic Heart Transplantation in Mice. | Chen, W., et al. 2018. Reg Anesth Pain Med. 43: 509-515. PMID: 29509567
- Dexmedetomidine attenuates H2O2-induced neonatal rat cardiomyocytes apoptosis through mitochondria- and ER-medicated oxidative stress pathways. | Liu, XR., et al. 2018. Mol Med Rep. 17: 7258-7264. PMID: 29568958
- Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation through Upregulation of Programmed Cell Death Protein 1 in a Rat Spinal Cord Injury Model. | He, H., et al. 2018. J Neurotrauma. 35: 2591-2603. PMID: 29665726
- Effects of local dexmedetomidine administration on the neurotoxicity of ropivacaine for sciatic nerve block in rats. | Xue, X., et al. 2020. Mol Med Rep. 22: 4360-4366. PMID: 33000208
- Dexmedetomidine Attenuates Lung Injury in Toxic Shock Rats by Inhibiting Inflammation and Autophagy. | Li, ZB., et al. 2021. Arch Med Res. 52: 277-283. PMID: 33248818
- Immortalized canine adipose-derived mesenchymal stem cells alleviate gentamicin-induced acute kidney injury by inhibiting endoplasmic reticulum stress in mice and dogs. | He, W., et al. 2021. Res Vet Sci. 136: 39-50. PMID: 33582313
- 4D spatiotemporal modulation of biomolecules distribution in anisotropic corrugated microwrinkles via electrically manipulated microcapsules within hierarchical hydrogel for spinal cord regeneration. | Chiang, MY., et al. 2021. Biomaterials. 271: 120762. PMID: 33773400
- Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1/miR-194/SIRT1 signaling pathway. | Gu, XX., et al. 2021. J Inflamm (Lond). 18: 20. PMID: 34039367
Inhibitor of:
SNFT.Activator of:
AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dexmedetomidine hydrochloride, 10 mg | sc-205290 | 10 mg | $159.00 | |||
Dexmedetomidine hydrochloride, 50 mg | sc-205290A | 50 mg | $490.00 |