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Dexamethasone Sodium Phosphate (CAS 2392-39-4)

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Alternate Names:
(11b, 16a)-9-Fluoro-11,17,21-trihydroxy-16- methylpregna-1,4-diene-3,20-dione 21-phosphate disodium salt; Dexamethasone 21-Phosphate Disodium Salt; Ak-Dex; Baldex; Dalalone; Dezone; Hexadrol; Oradexon; Soldesam
Application:
Dexamethasone Sodium Phosphate is an inducer of apoptosis and inhibitor of the sodium phosphate symporter
CAS Number:
2392-39-4
Purity:
≥98%
Molecular Weight:
516.4
Molecular Formula:
C22H28FO8P•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dexamethasone Sodium Phosphate is a systemic corticosteroid. Dexamethasone Sodium Phosphate induces apoptosis and inhibits sodium phosphate symporter. Dexamethasone Sodium Phosphate is also used in the treatment of emetic effects of cancer therapy and epicondylitis. Dexamethasone Sodium Phosphate is an activator of GR.


Dexamethasone Sodium Phosphate (CAS 2392-39-4) References

  1. [Effect of Epstein-Barr virus latent membrane protein 1 (LMP1) on apoptosis of nasopharyngeal carcinoma cell line CNE1].  |  Chen, Y. and Chen, XY. 2002. Ai Zheng. 21: 498-503. PMID: 12452040
  2. Iontophoretic administration of dexamethasone sodium phosphate for acute epicondylitis. A randomized, double-blinded, placebo-controlled study.  |  Nirschl, RP., et al. 2003. Am J Sports Med. 31: 189-95. PMID: 12642251
  3. Visual deterioration in giant cell arteritis patients while on high doses of corticosteroid therapy.  |  Hayreh, SS. and Zimmerman, B. 2003. Ophthalmology. 110: 1204-15. PMID: 12799248
  4. [Using chamber technique for studying the permeability of dexamethasone sodium phosphate liposome through rabbit colon mucosa in vitro].  |  Li, GF., et al. 2004. Di Yi Jun Yi Da Xue Xue Bao. 24: 11-4. PMID: 14724084
  5. Stability of dexamethasone sodium phosphate in rat plasma.  |  Samtani, MN. and Jusko, WJ. 2005. Int J Pharm. 301: 262-6. PMID: 16054309
  6. Comparison of topical 0.7% dexamethasone-cyclodextrin with 0.1% dexamethasone sodium phosphate for postcataract inflammation.  |  Saari, KM., et al. 2006. Graefes Arch Clin Exp Ophthalmol. 244: 620-6. PMID: 16217662
  7. Determination of dexamethasone and dexamethasone sodium phosphate in human plasma and cochlear perilymph by liquid chromatography/tandem mass spectrometry.  |  Zhang, M., et al. 2011. J Chromatogr B Analyt Technol Biomed Life Sci. 879: 17-24. PMID: 21112257
  8. Intratympanic versus intravenous delivery of dexamethasone and dexamethasone sodium phosphate to cochlear perilymph.  |  Bird, PA., et al. 2011. Otol Neurotol. 32: 933-6. PMID: 21725263
  9. Stability-Indicating HPLC Method for Simultaneous Determination of Chloramphenicol, Dexamethasone Sodium Phosphate and Tetrahydrozoline Hydrochloride in Ophthalmic Solution.  |  AlAani, H. and Alnukkary, Y. 2016. Adv Pharm Bull. 6: 137-41. PMID: 27123429
  10. Calcium ion cross-linking alginate/dexamethasone sodium phosphate hybrid hydrogel for extended drug release.  |  Zhang, R., et al. 2019. Colloids Surf B Biointerfaces. 175: 569-575. PMID: 30580147
  11. Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization.  |  Wang, B., et al. 2019. Nanomedicine. 17: 119-123. PMID: 30677499
  12. Silk fibroin hydrogel/dexamethasone sodium phosphate loaded chitosan nanoparticles as a potential drug delivery system.  |  Akrami-Hasan-Kohal, M., et al. 2021. Colloids Surf B Biointerfaces. 205: 111892. PMID: 34107443
  13. Environmental Risk Assessment of Dexamethasone Sodium Phosphate and Tocilizumab Mixture in Zebrafish Early Life Stage (Danio rerio).  |  Di Paola, D., et al. 2022. Toxics. 10: PMID: 35736888
  14. Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy.  |  Cassileth, PA., et al. 1983. Arch Intern Med. 143: 1347-9. PMID: 6347109
  15. Stability of ondansetron hydrochloride and dexamethasone sodium phosphate in infusion bags and syringes for 32 days.  |  Hagan, RL., et al. 1996. Am J Health Syst Pharm. 53: 1431-5. PMID: 8781690

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dexamethasone Sodium Phosphate, 100 mg

sc-204715
100 mg
$55.00

Dexamethasone Sodium Phosphate, 500 mg

sc-204715A
500 mg
$158.00

how is the uv spectra?

Asked by: sey62
Thank you for your question. It is unclear exactly what information you are requesting about this chemical, L-2-Amino-3-hydroxybutanoic acid 3-phosphate: sc-295240. Please contact our Technical Service Department and we would be happy to help you. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-05-10

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a white to yellowish powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-16
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Rated 5 out of 5 by from Wang XW; et alWang XW; et al. (PubMed ID: 26214469) confirmed that Dexamethasone Sodium Phosphate increased inhibition of proliferation in CEM cells and cytotoxic activity in Jurkat cells. -SCBT Publication Review
Date published: 2015-06-15
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Dexamethasone Sodium Phosphate is rated 5.0 out of 5 by 1.
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