Dexamethasone Labeled d5 (contains d2) (CAS 50-02-2 (unlabeled))

Physical State :

Solid

Solubility :

Soluble in water (0.1 mg/ml), ethanol (6 mg/ml at 25 °C), DMSO (79 mg/ml at 25 °C), DMF (~25 mg/ml), and methanol. (unlabeled)

Storage :

Store at -20° C

Melting Point :

230-232° C

Boiling Point :

~568.2° C at 760 mmHg (Predicted) (unlabeled)

Density :

~1.3 g/cm³ (Predicted) (unlabeled)

Refractive Index :

n²⁰_D 1.59 (Predicted) (unlabeled)

Optical Activity :

α20_D +75°, c = 1 in doxane (unlabeled)

IC50 :

Inhibitory activity against production of nitric oxide induced by interferon gamma in mouse macrophages: IC₅₀ = 0.1 nM; GR: IC₅₀ = 0.51 nM (human); HFF: IC₅₀ = 0.51 nM (human); RPMI-8226: IC₅₀ = 6.5 nM (human); THP-1: IC₅₀ = 7 nM (human) (unlabeled)

Ki Data :

GR: K_i= 1.1 nM (human); MCR: K_i= 7.2 nM (human); Progesterone receptor: K_i= 3.04 µM (bovine); Androgen Receptor: K_i= 16.37 µM (rat); Fatty acid-binding protein, liver: K_i= 22.1 µM (rat) (unlabeled)

pK Values :

pK_a: 12.13 (Predicted) (unlabeled)

WGK Germany :

2 (unlabeled)

RTECS :

TU3980000 (unlabeled)

PubChem CID :

Merck Index :

14: 2943 (unlabeled)

MDL Number :

MFCD00064136 (unlabeled)

EC Number :

200-003-9 (unlabeled)

Beilstein Registry :

2066651 (unlabeled)

SMILES :

[2H]C1=C2[C@](C=CC1=O)([C@]3([C@H](C[C@]4([C@H]([C@@H]3CC2([2H])[2H])C[C@H]([C@@]4(C(=O)C([2H])([2H])O)O)C)C)O)F)C