Date published: 2025-10-4

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Dexamethasone-d5 (CAS 358731-91-6)

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Alternate Names:
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-pregna-1,4-diene-3,20-dione-d5
CAS Number:
358731-91-6
Molecular Weight:
397.49
Molecular Formula:
C22H24D5FO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dexamethasone-d5 is a deuterium-labeled analog of dexamethasone, a glucocorticoid. Dexamethasone-d5 may be used as an internal standard to achieve more accurate quantification in mass spectrometry-based assays. The incorporation of deuterium atoms results in a slight mass difference that allows it to be distinguished from its non-labeled counterpart, yet it behaves almost identically in biochemical pathways. This isotopic labeling is in studies investigating the metabolism and environmental fate of dexamethasone, providing insights without the interference encountered with non-labeled substances. Dexamethasone-d5 is utilized in pharmacokinetic studies to understand the dynamics of glucocorticoid action in various experimental applications, facilitating the exploration of their biochemical and physiological impacts in a controlled manner.


Dexamethasone-d5 (CAS 358731-91-6) References

  1. Physicochemical pharmacokinetics as an optimization tool for generic development: A case study.  |  Horkovics-Kovats, S., et al. 2018. Eur J Pharm Sci. 111: 349-357. PMID: 29032305
  2. Immunosuppression by a subconjunctival implant releasing dexamethasone in a rabbit model of penetrating keratoplasty.  |  Crouzet, E., et al. 2018. Br J Ophthalmol. 102: 692-699. PMID: 29437570
  3. Binding of Small Molecule Drugs to Porcine Vitreous Humor.  |  Rimpelä, AK., et al. 2018. Mol Pharm. 15: 2174-2179. PMID: 29648838
  4. Validation of direct method to quantify dexamethasone in human aqueous humor by LC-MS/MS.  |  Ferreira, MS., et al. 2018. Bioanalysis. 10: 1361-1370. PMID: 30182725
  5. A holistic strategy for discovering structural analogues of drug residues in meat using characteristic structural fragments filtering by high-resolution Orbitrap mass spectrometry.  |  Liu, XM., et al. 2021. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 38: 81-94. PMID: 33170098
  6. Method-Specific Cortisol and Dexamethasone Thresholds Increase Clinical Specificity of the Dexamethasone Suppression Test for Cushing Syndrome.  |  Vogg, N., et al. 2021. Clin Chem. 67: 998-1007. PMID: 33997885
  7. A sensitive UPLC-APCI-MS/MS method for the determination of dexamethasone and its application in an ocular tissue distribution study in rabbits following topical administration  |  Murali K. Matta, *a Suresh Narayanasamy,a Christopher D. Thomas,a Lin Xu,a Sharron Stewart,a Ashok Chockalingam,a Vikram Patela and Rodney Rousea. 2018. Analytical Methods. 2307-2316.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dexamethasone-d5, 1 mg

sc-499772
1 mg
$562.00

Dexamethasone-d5, 10 mg

sc-499772A
10 mg
$4039.00

Dexamethasone-d5, 50 mg

sc-499772B
50 mg
$20104.00

Dexamethasone-d5, 100 mg

sc-499772C
100 mg
$32140.00