Dexamethasone β-D-Glucuronide Sodium Salt (CAS 105088-08-2)

Dexamethasone β-D-Glucuronide Sodium Salt is a water-soluble derivative of dexamethasone, a potent synthetic glucocorticoid, which is linked through a glucuronidation process to a β-D-glucuronic acid, conferring increased solubility in aqueous solutions. This modification significantly enhances its utility in biochemical assays and research studies focusing on the metabolism and excretion of glucocorticoids, as well as the glucuronidation process itself. The conjugation with glucuronic acid makes it useful in understanding the role of glucuronidation in drug metabolism and clearance. Its water solubility enables easier handling and application in in vitro studies, facilitating its use in cellular assays to study glucocorticoid receptor interactions and the mechanisms underlying the modulation of gene expression. By serving as a model compound, Dexamethasone β-D-Glucuronide Sodium Salt aids in elucidating the pathways through which glucocorticoids are metabolized and ultimately excreted, providing insights into the broader field of steroid pharmacokinetics.