Date published: 2026-5-9

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Dexamethasone Acetate (CAS 1177-87-3)

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Application:
Dexamethasone Acetate is a glucocorticoid
CAS Number:
1177-87-3
Purity:
≥99%
Molecular Weight:
434.5
Molecular Formula:
C24H31FO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dexamethasone Acetate is a glucocorticoid with anti-inflammatory properties. One possible mode of action of the anti-inflammatory properties has been documented by Dexamethasone Acetate inhibitiing upregulation of ICAM-1 (intercellular adhesion molecule-1) in cultured human mast cells. The compound also displays anti mitotic activity against chemically transformed mouse fibroblasts by halting mitosis from entering the S-phase. Dexamethasone Acetate has also been determined to markedly decrease the number of activated macrophages. In addition, Dexamethasone Acetate has been observed to significantly decrease mRNA levels of TPH2 (tryptophan hydroxylase-2) in the raphe nuclei of C57/Bl6 mice.


Dexamethasone Acetate (CAS 1177-87-3) References

  1. Expression of adhesion molecules on cord-blood-derived, cultured human mast cells and effect of dexamethasone on intercellular adhesion molecule-1 expression on the mast cells treated by phorbol myristate acetate.  |  Inamura, H., et al. 2001. Allergy. 56: 672-8. PMID: 11421927
  2. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice.  |  Clark, JA., et al. 2008. Mol Psychiatry. 13: 498-506. PMID: 17622221
  3. Dexamethasone acetate encapsulation into Trojan particles.  |  Gómez-Gaete, C., et al. 2008. J Control Release. 128: 41-9. PMID: 18374442
  4. Antimitogenic effects of dexamethasone in chemically transformed mouse fibroblasts.  |  Fagot, D., et al. 1991. Endocrinology. 129: 1033-41. PMID: 1906802
  5. In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system.  |  Wang, MT., et al. 2010. Int J Nanomedicine. 5: 487-97. PMID: 20957171
  6. Mucoadhesive dexamethasone acetate-polymyxin B sulfate cationic ocular nanoemulsion--novel combinatorial formulation concept.  |  Li, X., et al. 2016. Pharmazie. 71: 327-33. PMID: 27455551
  7. Simultaneous determination the concentration change of ketoconazole and dexamethasone acetate: application to drug-drug interaction in human keratinocyte.  |  Li, L., et al. 2020. J Pharm Biomed Anal. 188: 113396. PMID: 32535269
  8. Determination of dexamethasone acetate in CETETH 20-based in liquid crystalline systems using HPLC.  |  Oyafuso, MH., et al. 2021. Biomed Chromatogr. 35: e5054. PMID: 33314174
  9. Dexamethasone Acetate Nanocrystals, Characterization and Dissolution Studies in Presence of Polymorphic Phases.  |  da Gama Bastos, FLA., et al. 2023. Pharm Nanotechnol. 11: 373-382. PMID: 37018531
  10. The effect of RU 486 and related compounds on cultured macrophage differentiation and function.  |  Roberts, CP., et al. 1996. Am J Obstet Gynecol. 175: 248-57; discussion 257-9. PMID: 8765239

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dexamethasone Acetate, 100 mg

sc-204714
100 mg
$58.00

Dexamethasone Acetate, 500 mg

sc-204714A
500 mg
$122.00