Date published: 2025-12-18

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Dexamethasone (CAS 50-02-2)

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Alternate Names:
Dexamethasone is also known as MK-125.
Application:
Dexamethasone is a glucocorticoid which induces the production of phospholipase A2 inhibitory protein
CAS Number:
50-02-2
Purity:
≥98%
Molecular Weight:
392.46
Molecular Formula:
C22H29FO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone may act to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts, and inhibition of phosphorylation of Rb protein. It has been observed to induce apoptosis in human thymocytes and eosinophils. Conversely, Dexamethasone has also been observed to inhibit apoptosis in neutrophils.


Dexamethasone (CAS 50-02-2) References

  1. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.  |  Chauhan, D., et al. 2000. J Biol Chem. 275: 27845-50. PMID: 10880513
  2. In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability.  |  Avlasevich, SL., et al. 2006. Environ Mol Mutagen. 47: 56-66. PMID: 16180205
  3. In vitro effects of dexamethasone on mouse ovarian function and pre-implantation embryo development.  |  Van Merris, V., et al. 2007. Reprod Toxicol. 23: 32-41. PMID: 17000079
  4. Inhibition of the induction of nitric oxide synthase by glucocorticoids: yet another explanation for their anti-inflammatory effects?  |  Moncada, S. and Palmer, RM. 1991. Trends Pharmacol Sci. 12: 130-1. PMID: 1712139
  5. Evaluation of novel high-throughput embryonic stem cell tests with new molecular markers for screening embryotoxic chemicals in vitro.  |  Suzuki, N., et al. 2011. Toxicol Sci. 124: 460-71. PMID: 21964422
  6. Onset of neoplastic phenotype in an epithelial cell strain from adult BALB/c mouse lung alveolus.  |  Smith, GJ., et al. 1986. J Natl Cancer Inst. 76: 73-9. PMID: 3001399
  7. Differential effects of aspirin and dexamethasone on phospholipase A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4.  |  Clark, MA., et al. 1986. Prostaglandins. 32: 703-8. PMID: 3103170
  8. Long-Term in vivo Release Profile of Dexamethasone-Loaded Silicone Rods Implanted Into the Cochlea of Guinea Pigs.  |  Liebau, A., et al. 2019. Front Neurol. 10: 1377. PMID: 32038458
  9. Shifts in the gut microbiota of mice in response to dexamethasone administration.  |  Zhao, H., et al. 2020. Int Microbiol. 23: 565-573. PMID: 32356148
  10. Anti-Inflammatory Polymeric Nanoparticles Based on Ketoprofen and Dexamethasone.  |  Espinosa-Cano, E., et al. 2020. Pharmaceutics. 12: PMID: 32751993
  11. Effects of dexamethasone on the morphology, gene expression and hepatic histology in adult female mosquitofish (Gambusia affinis).  |  Zhong, L., et al. 2021. Chemosphere. 274: 129797. PMID: 33545586
  12. Probiotic fermentation of Ganoderma lucidum fruiting body extracts promoted its immunostimulatory activity in mice with dexamethasone-induced immunosuppression.  |  Li, Y., et al. 2021. Biomed Pharmacother. 141: 111909. PMID: 34328088
  13. Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle.  |  Fearnhead, HO., et al. 1994. Biochem Pharmacol. 48: 1073-9. PMID: 7945400
  14. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro.  |  Jaiswal, N., et al. 1997. J Cell Biochem. 64: 295-312. PMID: 9027589
  15. In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids.  |  Smith, CL. and Kreutner, W. 1998. Arzneimittelforschung. 48: 956-60. PMID: 9793625
  16. Cytochrome P450 1A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro.  |  Fung, J., et al. 1999. Mutat Res. 438: 1-12. PMID: 9858665

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dexamethasone, 100 mg

sc-29059
100 mg
$76.00

Dexamethasone, 1 g

sc-29059B
1 g
$82.00

Dexamethasone, 5 g

sc-29059A
5 g
$367.00

can i use this for neutraliztion of beta defensin -3 directly in my experiments

Asked by: saiabbi
Thank you for your question. Dexamethasone is an anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone may act to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts, and inhibition of phosphorylation of Rb protein.
Answered by: Tech Support Europe
Date published: 2025-02-14

진행하는 실험을 위해 해당 COA에 명시되어있는 25mg/ml보다 더 높은 농도로 reconstitution 해야할 것 같은데, 혹시 DMSO에 녹인 dexamethasone을 37도에서 데워서 사용해도 되나요? 혹은 dexamethasone을 넣은 media를 waterbath에 데워도 되는지 여쭙고 싶습니다.

Asked by: sinnnnni
Thank you for your question. https://www.scbt.com/resources/distributors KOREA For ordering or product information contact us at: Essence Medical Inc. 417 Leaders B/D, Yatapdong 342-1 Bundanggu Seongnam Gyeonggi-do Korea Phone: 82-31-707-1544 Fax: 82-31-707-1999 Email: info@essencemedical.com Website: www.essencemedical.com Koram Biotech Corporation 6F, Koram Venture Building 907-1 Daechi-Dong Kang Nam-Ku Seoul 135-080 Korea Phone: 82 (2) 556-0311 Fax: 82 (2) 556-0828 Email: koram@korambiotech.com Website: www.korambiotech.com
Answered by: Ling Chen
Date published: 2024-05-20

I want 50mg dexamethasone as gift sample. As I want to carry some research project on it. Can you supply that ? Kindly respond

Asked by: Bharti
Thank you for your question. We do not supply samples of our biochemicals, so unfortunately we are not able to provide a sample of this product.
Answered by: Tech Service
Date published: 2020-02-06
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Rated 5 out of 5 by from Dexamethasone (CAS 50Dexamethasone (CAS 50-02-2) was used to determine glucocorticoid receptor binding within the human genome by measuring the change in mRNA expression after treatment (PubMed ID 19801529). -SCBT Publication Review
Date published: 2015-01-14
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Dexamethasone is rated 5.0 out of 5 by 1.
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