Date published: 2026-4-25

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Desvenlafaxine hydrochloride (CAS 300827-87-6)

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Alternate Names:
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-phenol hydrochloride
Application:
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor and a major active metabolite of venlafaxine
CAS Number:
300827-87-6
Purity:
≥98%
Molecular Weight:
299.84
Molecular Formula:
C16H25NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Desvenlafaxine hydrochloride, a synthetic form of the phenethylamine derivative, primarily acts as a serotonin-norepinephrine reuptake inhibitor (SNRI). By selectively blocking the reabsorption of serotonin and norepinephrine in the brain, it significantly alters the balance of these neurotransmitters, which are critical for mood regulation and cognitive processes. This mechanism of action makes it a focus of interest in neuroscientific research, particularly in studies exploring the neurochemical basis of affective disorders. Its ability to modulate neurotransmitter levels without directly stimulating receptor activity provides a unique tool for dissecting the complex interactions within neural networks. Additionally, desvenlafaxine hydrochloride′s pharmacokinetic properties, including its bioavailability and metabolic pathway, are subjects of pharmacological studies aimed at understanding the dynamics of SNRI compounds within biological systems. As such, it serves not only as a candidate for investigating the pathophysiology of neuropsychiatric conditions but also as a model compound for developing new strategies in the synthesis and application of SNRI drugs in research applications.


Desvenlafaxine hydrochloride (CAS 300827-87-6) References

  1. Venlafaxine in human breast milk and nursing infant plasma: determination of exposure.  |  Newport, DJ., et al. 2009. J Clin Psychiatry. 70: 1304-10. PMID: 19607765
  2. Desvenlafaxine and venlafaxine exert minimal in vitro inhibition of human cytochrome P450 and P-glycoprotein activities.  |  Oganesian, A., et al. 2009. Psychopharmacol Bull. 42: 47-63. PMID: 19629022
  3. Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine.  |  Bachmeier, CJ., et al. 2011. Biopharm Drug Dispos. 32: 233-44. PMID: 21446053
  4. Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors.  |  Neil, CJ., et al. 2012. Heart Lung Circ. 21: 203-5. PMID: 22285074
  5. An indirect comparison of the efficacy and safety of desvenlafaxine and venlafaxine using placebo as the common comparator.  |  Coleman, KA., et al. 2012. CNS Spectr. 17: 131-41. PMID: 22883424
  6. Risk of hair loss with different antidepressants: a comparative retrospective cohort study.  |  Etminan, M., et al. 2018. Int Clin Psychopharmacol. 33: 44-48. PMID: 28763345
  7. A standardization of the Novelty-Suppressed Feeding Test protocol in rats.  |  Blasco-Serra, A., et al. 2017. Neurosci Lett. 658: 73-78. PMID: 28803957
  8. Effects of desvenlafaxine versus placebo on MDD symptom clusters: A pooled analysis.  |  Katzman, MA., et al. 2020. J Psychopharmacol. 34: 280-292. PMID: 31913085
  9. Desvenlafaxine-associated hyperglycemia: A case report and literature review.  |  Mekonnen, AD., et al. 2020. Ment Health Clin. 10: 85-89. PMID: 32420005
  10. New generation antidepressants for depression in children and adolescents: a network meta-analysis.  |  Hetrick, SE., et al. 2021. Cochrane Database Syst Rev. 5: CD013674. PMID: 34029378
  11. Impact of maternal desvenlafaxine exposure on brain development in pregnant albino rats and their fetuses.  |  Ahmed, SH., et al. 2022. J Biochem Mol Toxicol. 36: e23062. PMID: 35363936
  12. A Comparative Study on Safety and Efficacy of Desvenlafaxine Versus Sertraline in Depression.  |  Ch, S., et al. 2022. Cureus. 14: e22717. PMID: 35371643
  13. Acute Efficacy and Safety of Escitalopram Versus Desvenlafaxine and Vortioxetine in the Treatment of Depression With Cognitive Complaint: A Rater-Blinded Randomized Comparative Study.  |  Lee, SH., et al. 2022. Psychiatry Investig. 19: 268-280. PMID: 35500900
  14. Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis.  |  Kishi, T., et al. 2023. Mol Psychiatry. 28: 402-409. PMID: 36253442

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Desvenlafaxine hydrochloride, 10 mg

sc-255071
10 mg
$126.00