Molecular structure of Desmycosin, CAS Number: 11032-98-7
Desmycosin (CAS 11032-98-7)
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Alternate Names:
4A-O-De(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)tylosin; Demycarosyltylosin; Tylosin B
Application:
Desmycosin is a 16-membered macrolide antibiotic and a metabolite of Tylosin
CAS Number:
11032-98-7
Molecular Weight:
771.93
Molecular Formula:
C39H65NO14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Desmycosin is a 16-membered macrolide antibiotic and a metabolite of Tylosin (sc-500492). Desmycosin is also a precursor to Tilmicosin (sc-213047) As a metabolite of Tylosin, Desmycosin showcases the metabolic versatility within microbial systems or synthetic pathways, where it undergoes structural modifications to enhance or modify its antibacterial spectrum.
Desmycosin (CAS 11032-98-7) References
- New amidino-benzimidazolyl derivatives of tylosin and desmycosin. | Hranjec, M., et al. 2002. J Antibiot (Tokyo). 55: 308-14. PMID: 12014447
- New derivatives of tylosin: chemical and electrochemical oxidation products of desmycosin. | Mandić, Z., et al. 2002. J Antibiot (Tokyo). 55: 807-13. PMID: 12458770
- Electrochemical reduction of desmycosin, structure investigation and antibacterial evaluation of the resulting products. | Iveković, D., et al. 2003. Eur J Pharm Sci. 18: 323-8. PMID: 12694884
- Tylosin, a new antibiotic. II. Isolation, properties, and preparation of desmycosin, a microbiologically active degradation product. | HAMILL, RL., et al. 1961. Antibiot Chemother (Northfield). 11: 328-34. PMID: 13711004
- Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors. | Sumbatyan, NV., et al. 2003. Biochemistry (Mosc). 68: 1156-8. PMID: 14616087
- Semisynthetic macrolide antibacterials derived from tylosin. Synthesis and structure-activity relationships of novel desmycosin analogues. | Mutak, S., et al. 2004. J Med Chem. 47: 411-31. PMID: 14711312
- Synthesis of 2-methyl 16-membered macrolide derived from tylosin. | Terui, Y., et al. 2006. J Antibiot (Tokyo). 59: 98-104. PMID: 16629410
- Degradation of incurred tylosin to desmycosin--implications for residue analysis of honey. | Thompson, TS., et al. 2007. Anal Chim Acta. 586: 304-11. PMID: 17386728
- Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. | Tsutsui, A., et al. 2013. J Antibiot (Tokyo). 66: 191-4. PMID: 23232930
- Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. | Debono, M., et al. 1989. J Antibiot (Tokyo). 42: 1253-67. PMID: 2668243
- Multicomponent synthesis of α-acylamino and α-acyloxy amide derivatives of desmycosin and their activity against gram-negative bacteria. | Budragchaa, T., et al. 2019. Bioorg Med Chem. 27: 3237-3247. PMID: 31229422
- Tylosin A and desmycosin in honey by salting-out assisted liquid-liquid extraction and aqueous normal phase ultraperformance liquid chromatography-tandem mass spectrometry. | Thompson, TS., et al. 2019. Anal Bioanal Chem. 411: 6509-6518. PMID: 31359120
- Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome. | Khairullina, ZZ., et al. 2022. Biochemistry (Mosc). 87: 871-889. PMID: 36180983
- Terminal stages in the biosynthesis of tylosin. | Seno, ET., et al. 1977. Antimicrob Agents Chemother. 11: 455-61. PMID: 855999
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desmycosin, 100 mg | sc-500155 | 100 mg | $600.00 | |||
Desmycosin, 500 mg | sc-500155A | 500 mg | $2000.00 |