Molecular structure of Desmopressin acetate, CAS Number: 16679-58-6 (free base)
Desmopressin acetate (CAS 16679-58-6 (free base))
Alternate Names:
[deamino-Cys1, D-Arg8]-Vasopressin acetate
Application:
Desmopressin acetate is a potent and selective vasopressin V2 receptor agonist
CAS Number:
16679-58-6 (free base)
Molecular Weight:
1069.22 (anhydrous free base basis)
Molecular Formula:
C46H64N14O12S2 · xC2H4O2 · yH2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Desmopressin acetate hydrate is an analogue, produced artificially, of the antidiuretic hormone vasopressin. It functions by binding to vasopressin V2 receptors in the renal collecting duct, leading to an increase in water reabsorption and a decrease in urine production. Desmopressin Acetate Hydrate′s mechanism of action involves the activation of adenylate cyclase, which results in the insertion of aquaporin-2 water channels into the apical membrane of the renal collecting duct cells. This leads to an increase in water permeability and reabsorption, ultimately reducing urine output. Desmopressin Acetate Hydrate′s function in experimental applications involves its role in studying the regulation of water balance and kidney function.
Desmopressin acetate (CAS 16679-58-6 (free base)) References
- Dermal delivery of desmopressin acetate using colloidal carrier systems. | Getie, M., et al. 2005. J Pharm Pharmacol. 57: 423-7. PMID: 15831201
- The role of desmopressin acetate in patients undergoing coronary artery bypass surgery. A controlled clinical trial with thromboelastographic risk stratification. | Mongan, PD. and Hosking, MP. 1992. Anesthesiology. 77: 38-46. PMID: 1610009
- Does desmopressin acetate prophylaxis reduce blood loss after valvular heart operations? A randomized, double-blind study. | Ansell, J., et al. 1992. J Thorac Cardiovasc Surg. 104: 117-23. PMID: 1614196
- Use of desmopressin acetate in severe hyponatremia in the intensive care unit. | Rafat, C., et al. 2014. Clin J Am Soc Nephrol. 9: 229-37. PMID: 24262506
- Desmopressin acetate (DDAVP)-associated hyponatremia and brain damage: a case series. | Achinger, SG., et al. 2014. Nephrol Dial Transplant. 29: 2310-5. PMID: 25107337
- Desmopressin acetate nasal spray for adults with nocturia. | Cohn, JA., et al. 2017. Expert Rev Clin Pharmacol. 10: 1281-1293. PMID: 29048257
- Application and validation of a coaxial liquid core waveguide fluorescence detector for the permeation analysis of desmopressin acetate. | Kottke, D., et al. 2021. Talanta. 226: 122145. PMID: 33676696
- Development and evaluation of a composite dosage form containing desmopressin acetate for buccal administration. | Kottke, D., et al. 2021. Int J Pharm X. 3: 100082. PMID: 34195604
- Experimental Design Based Optimization and Ex Vivo Permeation of Desmopressin Acetate Loaded Elastic Liposomes Using Rat Skin. | Altamimi, MA., et al. 2021. Pharmaceutics. 13: PMID: 34371738
- The use of desmopressin acetate (DDAVP) as a test of the fibrinolytic capacity of patients--analysis of responders and non-responders. | Brommer, EJ., et al. 1982. Thromb Haemost. 48: 156-61. PMID: 6817444
- Primary nocturnal enuresis: a comparison among observation, imipramine, desmopressin acetate and bed-wetting alarm systems. | Monda, JM. and Husmann, DA. 1995. J Urol. 154: 745-8. PMID: 7609169
- Desmopressin acetate in cardiac surgery: a double-blind, randomized study. | Temeck, BK., et al. 1994. South Med J. 87: 611-5. PMID: 8202769
- Use of desmopressin acetate to reduce blood transfusion requirements during cardiac surgery in patients with acetylsalicylic-acid-induced platelet dysfunction. | Sheridan, DP., et al. 1994. Can J Surg. 37: 33-6. PMID: 8306217
- Desmopressin acetate and nocturnal enuresis: how much do we know? | Moffatt, ME., et al. 1993. Pediatrics. 92: 420-5. PMID: 8361796
- Influence of desmopressin acetate on homologous blood requirements in cardiac surgical patients pretreated with aspirin. | Dilthey, G., et al. 1993. J Cardiothorac Vasc Anesth. 7: 425-30. PMID: 8400098
Activator of:
AVP Receptor V2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desmopressin acetate, 100 µg | sc-300417 | 100 µg | $84.00 | |||
Desmopressin acetate, 500 µg | sc-300417A | 500 µg | $245.00 |