Molecular structure of Desfuroyl Ceftiofur, CAS Number: 120882-22-6
Desfuroyl Ceftiofur (CAS 120882-22-6)
Alternate Names:
Desfuroyl Ceftiofur also known as (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(mercaptomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; DFC; Defuroylceftiofur
Application:
Desfuroyl Ceftiofur is a Ceftiofur metabolite that is is microbiologically active and can be used as a primary hydrolysis product
CAS Number:
120882-22-6
Purity:
≥85%
Molecular Weight:
429.49
Molecular Formula:
C14H15N5O5S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Desfuroyl Ceftiofur (DFT) is a metabolite of Ceftiofur, which is microbiologically active. Desfuroyl Ceftiofur can be used as a primary hydrolysis product, which is the most abundant metabolite in bovine blood. It may act to have bactericidal activity, meaning it kills bacteria by disrupting the bacterial cell wall. Additionally, it has anti-inflammatory, analgesic, and immunomodulatory effects.
Desfuroyl Ceftiofur (CAS 120882-22-6) References
- Determination of ceftiofur in bovine plasma by HPLC-DAD. | Jacobson, GA., et al. 2006. J Pharm Biomed Anal. 40: 1249-52. PMID: 16242891
- Disposition of desfuroylceftiofur acetamide in serum, placental tissue, fetal fluids, and fetal tissues after administration of ceftiofur crystalline free acid (CCFA) to pony mares with placentitis. | Macpherson, ML., et al. 2013. J Vet Pharmacol Ther. 36: 59-67. PMID: 22449008
- Liquid chromatographic determination of desfuroylceftiofur metabolite of ceftiofur as residue in cattle plasma. | Jaglan, PS., et al. 1990. J Assoc Off Anal Chem. 73: 26-30. PMID: 2312509
- Comparative pharmacokinetics of desfuroylceftiofur acetamide after intramuscular versus subcutaneous administration of ceftiofur crystalline free acid to adult horses. | Fultz, L., et al. 2013. J Vet Pharmacol Ther. 36: 309-12. PMID: 23240662
- Can the unauthorised use of ceftiofur be detected in poultry? | Heinrich, K., et al. 2013. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30: 1733-8. PMID: 23869819
- Determination of ceftiofur metabolite desfuroylceftiofur cysteine disulfide in bovine tissues using liquid chromatography-tandem mass spectrometry as a surrogate marker residue for ceftiofur. | Feng, S., et al. 2014. J Agric Food Chem. 62: 5011-9. PMID: 24819974
- Pulmonary pharmacokinetics of desfuroylceftiofur acetamide after nebulisation or intramuscular administration of ceftiofur sodium to weanling foals. | Fultz, L., et al. 2015. Equine Vet J. 47: 473-7. PMID: 24975449
- Plasma pharmacokinetics of ceftiofur metabolite desfuroylceftiofur cysteine disulfide in holstein steers: application of nonlinear mixed-effects modeling. | Chiesa, OA., et al. 2016. J Vet Pharmacol Ther. 39: 149-56. PMID: 26112893
- PK/PD modeling of Ceftiofur Sodium against Haemophilus parasuis infection in pigs. | Li, XD., et al. 2019. BMC Vet Res. 15: 272. PMID: 31370843
- Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin. | Ahmadvand, P., et al. 2022. Int J Mol Sci. 23: PMID: 35563620
- Concentration of ceftiofur metabolites in the plasma and lungs of horses following intramuscular treatment. | Jaglan, PS., et al. 1994. J Vet Pharmacol Ther. 17: 24-30. PMID: 8196090
- Determination of ceftiofur and its metabolite desfuroylceftiofur in bovine serum and milk by ion-paired liquid chromatography. | Tyczkowska, KL., et al. 1993. J Chromatogr. 614: 123-34. PMID: 8496272
- In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. | Salmon, SA., et al. 1996. J Vet Diagn Invest. 8: 332-6. PMID: 8844576
- Controlled hydrolysis of ceftiofur sodium, a broad-spectrum cephalosporin; isolation and identification of hydrolysis products. | Koshy, KT. and Cazers, AR. 1997. J Pharm Sci. 86: 389-95. PMID: 9050811
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desfuroyl Ceftiofur, 1 mg | sc-207534D | 1 mg | $265.00 | |||
Desfuroyl Ceftiofur, 2.5 mg | sc-207534 | 2.5 mg | $437.00 | |||
Desfuroyl Ceftiofur, 5 mg | sc-207534A | 5 mg | $728.00 | |||
Desfuroyl Ceftiofur, 5 mg | sc-207534A-CW | 5 mg | $895.00 | |||
Desfuroyl Ceftiofur, 10 mg | sc-207534B | 10 mg | $1290.00 | |||
Desfuroyl Ceftiofur, 25 mg | sc-207534C | 25 mg | $2601.00 |