Desformylflustrabromine hydrochloride is a positive allosteric modulator of AChR α 4 AChR β2 (α4β2 nicotinic acetylcholine receptors, nAChRs). It is additionally noted to selectively increase the ionic current through α4β2 in the presence of ACh (acetylcholine). Desformylflustrabromine hydrochloride shows a 14-fold selectivity of α4β2 versus α7, homomeric receptors is also observed. Other studies note the display of moderate cytotoxicity in HCT-116 cell cultures.
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