Desformylflustrabromine hydrochloride CAS: 951322-11-5
MF: C16H21BrN2•HCl
MW: 357.72

Desformylflustrabromine hydrochloride (CAS 951322-11-5)

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Alternate Names: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochloride
Application: Desformylflustrabromine hydrochloride is a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors
CAS Number: 951322-11-5
Purity: >98%
Molecular Weight: 357.72
Molecular Formula: C16H21BrN2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Desformylflustrabromine hydrochloride is a positive allosteric modulator of AChR α 4 AChR β2 (α4β2 nicotinic acetylcholine receptors, nAChRs). It is additionally noted to selectively increase the ionic current through α4β2 in the presence of ACh (acetylcholine). Desformylflustrabromine hydrochloride shows a 14-fold selectivity of α4β2 versus α7, homomeric receptors is also observed. Other studies note the display of moderate cytotoxicity in HCT-116 cell cultures.


References

1. Lysek, N., et al. 2002. Z. Naturforsch. 57: 1056-1061. PMID: 12562094

2. Sala, F., et al. 2005. Neurosci. Lett. 373: 144-149. PMID: 15567570

3. Kim, J.S., et al. 2007. Bioorg. Med. Chem. Lett. 17: 4855-4860. PMID: 17604168

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mM), and water (100 mM).
Storage :
Store at 4° C
IC50 :
Neuronal acetylcholine receptor; alpha4/beta2: EC5050 = 320 nM (human)
pK Values :
pKb: 10.38 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
56675778
MDL Number :
MFCD18086865
SMILES :
CC(C)(C=C)C1=C(C2=C(N1)C=C(C=C2)Br)CCNC.Cl

Download SDS (MSDS)

Certificate of Analysis

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