Desfluoro ezetimibe (CAS 302781-98-2)
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Desfluoro ezetimibe is a compound that is utilized in biochemical research, particularly in the study of lipid absorption and metabolism. In research applications, desfluoro ezetimibe is of interest for its role in modulating the enterohepatic circulation of bile acids. This compound is used to investigate the inhibition of the Niemann-Pick C1-like 1 (NPC1L1) transporter, which is involved in the intestinal uptake of cholesterol. Researchers employ desfluoro ezetimibe to understand the molecular mechanisms underlying cholesterol transport and the subsequent impact on cholesterol homeostasis. Additionally, it serves as a tool to explore the structure-activity relationship in analogs of ezetimibe, providing insights into the chemical features that contribute to biological activity. The compound′s effects on lipid profiles in model systems are also examined, contributing to a broader understanding of lipid modulation by small molecules.
Desfluoro ezetimibe (CAS 302781-98-2) References
- Detection of dehalogenation impurities in organohalogenated pharmaceuticals by UHPLC-DAD-HRESIMS. | Regalado, EL., et al. 2014. J Pharm Biomed Anal. 92: 1-5. PMID: 24469094
- Ultrafast separation of fluorinated and desfluorinated pharmaceuticals using highly efficient and selective chiral selectors bonded to superficially porous particles. | Barhate, CL., et al. 2015. J Chromatogr A. 1426: 241-7. PMID: 26643720
- Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations. | Bellur Atici, E. and Karlığa, B. 2015. J Pharm Anal. 5: 356-370. PMID: 29403950
- Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell. | Xiong, H., et al. 2021. Front Immunol. 12: 745111. PMID: 35087512
- Analytical quality by design-compliant retention modeling for exploring column interchangeabilities in separating ezetimibe and its related substances. | Ferencz, E., et al. 2022. J Chromatogr A. 1682: 463494. PMID: 36126559
- Simultaneous quantification of related substances of ezetimibe and simvastatin in combined dosage form using a novel stability-indicating liquid chromatographic method | P. R. Desai, P. J. Mehta, S. K. Ojha, and A. B. Chokshi. 2018. Acta Chromatographica. Volume 30: Issue 2: 85–94.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desfluoro ezetimibe, 2.5 mg | sc-499490 | 2.5 mg | $380.00 |