Molecular structure of Desethyl Chloroquine, CAS Number: 1476-52-4
Desethyl Chloroquine (CAS 1476-52-4)
Alternate Names:
N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine
Application:
Desethyl Chloroquine is a Chloroquine metabolite
CAS Number:
1476-52-4
Molecular Weight:
291.82
Molecular Formula:
C16H22ClN3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Desethyl Chloroquine is a metabolite of chloroquine, primarily researched for its biochemical properties and mechanisms of action in parasitology. It is a tool for investigating resistance mechanisms in malaria parasites, offering a window into how these organisms can evade certain compounds′ effects. In laboratory environments, Desethyl Chloroquine is used to study the action and metabolism of certain substances, as well as the molecular pathways affected by similar compounds. Its interaction with heme and potential to disrupt heme polymerization is a focal point in understanding the biochemical basis of its parent compound′s activity. Furthermore, Desethyl Chloroquine′s role in modulating immune responses is leveraged in immunological research to examine how structurally related compounds might influence cellular signaling pathways.
Desethyl Chloroquine (CAS 1476-52-4) References
- In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation. | Projean, D., et al. 2003. Drug Metab Dispos. 31: 748-54. PMID: 12756207
- Liquid chromatographic determination of amodiaquine in human plasma. | Dua, VK., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 803: 371-4. PMID: 15063350
- An improved high-performance liquid chromatographic determination of chloroquine and its major metabolite, desethylchloroquine, in human plasma. | Yakasai, IA. 2006. Eur J Drug Metab Pharmacokinet. 31: 1-4. PMID: 16715775
- HPLC with ultraviolet detection for the determination of chloroquine and desethylchloroquine in whole blood and finger-prick capillary blood dried on filter paper. | Cheomung, A. and Na-Bangchang, K. 2011. J Pharm Biomed Anal. 55: 1031-40. PMID: 21466937
- Prevalence and risk factors for chloroquine maculopathy and role of plasma chloroquine and desethylchloroquine concentrations in predicting chloroquine maculopathy. | Chiowchanwisawakit, P., et al. 2013. Int J Rheum Dis. 16: 47-55. PMID: 23441772
- Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD. | Zuluaga-Idárraga, L., et al. 2014. J Pharm Biomed Anal. 95: 200-6. PMID: 24682018
- Recent developments in the understanding of the pharmacokinetics and mechanism of action of chloroquine. | Titus, EO. 1989. Ther Drug Monit. 11: 369-79. PMID: 2662478
- Concentration-dependent mortality of chloroquine in overdose. | Watson, JA., et al. 2020. Elife. 9: PMID: 32639233
- Effects of hydroxychloroquine and its metabolites in patients with connective tissue diseases. | Eryavuz Onmaz, D., et al. 2021. Inflammopharmacology. 29: 1795-1805. PMID: 34743268
- Influence of route of administration on the pharmaco-kinetics of chloroquine and desethylchloroquine. | Salako, LA., et al. 1987. Bull World Health Organ. 65: 47-50. PMID: 3495365
- Relationship of cytochrome P450 gene polymorphisms with blood concentrations of hydroxychloroquine and its metabolites and adverse drug reactions. | Gao, B., et al. 2022. BMC Med Genomics. 15: 23. PMID: 35135554
- Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro. | Paludetto, MN., et al. 2023. Drug Metab Dispos. 51: 293-305. PMID: 36446607
- Sensitive method for the determination of chloroquine and its metabolite desethyl-chloroquine in human plasma and urine by high-performance liquid chromatography. | Bergqvist, Y. and Frisk-Holmberg, M. 1980. J Chromatogr. 221: 119-27. PMID: 7451613
Inhibitor of:
Peroxin 16.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desethyl Chloroquine, 2.5 mg | sc-207531 | 2.5 mg | $302.00 | |||
Desethyl Chloroquine, 25 mg | sc-207531A | 25 mg | $2561.00 |