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Desacetyl Bisacodyl (CAS 603-41-8)

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Alternate Names:
4,4-(2-Pyridinylmethylene)bisphenol; 4,4-Dihydroxydiphenyl(2-pyridyl)methane; Bis(4-hydroxyphenyl)(2-pyridyl)methane
Application:
Desacetyl Bisacodyl is the active form of Bisacodyl
CAS Number:
603-41-8
Molecular Weight:
277.32
Molecular Formula:
C18H15NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Desacetyl Bisacodyl is a compound that has garnered interest in the field of analytical chemistry, particularly in relation to its parent compound, Bisacodyl. Research on Desacetyl Bisacodyl focuses on its identification and quantification as a metabolite and degradation product. The study of its chemical stability is important for understanding the metabolic pathways and the environmental breakdown of the parent molecule. In addition, Desacetyl Bisacodyl serves as a reference standard in the development of analytical methods, such as liquid chromatography-mass spectrometry (LC-MS), which are essential for the accurate measurement of Bisacodyl and its related substances in various matrices. The compound′s structure, lacking the acetyl group present in Bisacodyl, is also of interest in investigations exploring the relationship between chemical structure and metabolic processes. Furthermore, researchers may examine the physicochemical properties of Desacetyl Bisacodyl, such as solubility and reactivity, which can be significant in the formulation and stability assessment of the parent compound in different preparations.


Desacetyl Bisacodyl (CAS 603-41-8) References

  1. Development and validation of three stability-indicating methods for determination of bisacodyl in pure form and pharmaceutical preparations.  |  Metwally, FH., et al. 2007. J AOAC Int. 90: 113-27. PMID: 17373442
  2. Desacetyl bisacodyl-induced epithelial Cl(-) secretion in rat colon and rectum.  |  Fujita, T., et al. 2016. Biomed Res. 37: 13-20. PMID: 26912136
  3. Least-Squares Regression and Spectral Residual Augmented Classical Least-Squares Chemometric Models for Stability-Indicating Analysis of Agomelatine and Its Degradation Products: A Comparative Study.  |  Naguib, IA., et al. 2016. J AOAC Int. 99: 386-95. PMID: 26987554
  4. Light-induced metal-free transformations of unactivated pyridotriazoles.  |  Zhang, Z., et al. 2019. Chem Sci. 10: 8399-8404. PMID: 31803418
  5. Duodenal and proximal jejunal motility inhibition associated with bisacodyl-induced colonic high-amplitude propagating contractions.  |  Dinning, PG., et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321: G325-G334. PMID: 34231391
  6. Bisacodyl Limits Chikungunya Virus Replication In Vitro and Is Broadly Antiviral.  |  LoMascolo, NJ., et al. 2022. Antimicrob Agents Chemother. 66: e0029222. PMID: 35652314
  7. Colonic Response to Physiological, Chemical, Electrical and Mechanical Stimuli; What Can Be Used to Define Normal Motility?  |  Dinning, PG. 2022. Adv Exp Med Biol. 1383: 125-132. PMID: 36587152
  8. Studies in the rat on the absorption, biliary excretion, laxative action and interference with intestinal transport of some oxyphenisatin derivatives.  |  Sund, RB., et al. 1979. Acta Pharmacol Toxicol (Copenh). 44: 251-9. PMID: 433618
  9. Qualitative and quantitative analysis of some synthetic, chemically acting laxatives in urine by gas chromatography-mass spectrometry.  |  Kok, RM. and Faber, DB. 1981. J Chromatogr. 222: 389-98. PMID: 6894448
  10. Intestinal handling of bisacodyl and picosulphate by everted sacs of the rat jejunum and stripped colon.  |  Hillestad, B., et al. 1982. Acta Pharmacol Toxicol (Copenh). 51: 388-94. PMID: 7180502
  11. Enterohepatic circulation, urinary excretion and laxative action of some bisacodyl derivatives after intragastric administration in the rat.  |  Sund, RB., et al. 1981. Acta Pharmacol Toxicol (Copenh). 48: 73-80. PMID: 7223440
  12. Structural changes in subdomain 2 of G-actin observed by fluorescence spectroscopy.  |  Moraczewska, J., et al. 1996. Biochem J. 317 (Pt 2): 605-11. PMID: 8713092
  13. Progress on Pyridotriazole Chemistry: Synthesis and Transformations  |  Prof. Dr. Ruwei Shen, Kaixin Yin, Mengyuan Yu, Xiaojie Li. 2023. Asian Journal of Organic Chemistry. 12.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Desacetyl Bisacodyl, 100 mg

sc-211246
100 mg
$312.00

Bonjour, je souhaiterai consulter un exemple de CoA concernant le Desacetyl Bisacodyl référence sc-211246. A l'avance merci.

Asked by: Gerald Lamborion
Merci pour votre question. Les certificats d'analyse sont disponibles sur demande, après commande et réception du produit, avec le numéro du lot reçu. Pour plus d'informations, veuillez contacter notre Service Technique.
Answered by: Technical Support Europe
Date published: 2018-07-26
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Rated 5 out of 5 by from MetwallyMetwally, FH. et al. (PubMed 17373442) developed three new, simple, sensitive, and accurate stability-indicating methods for quantitative determination of bisacodyl in the presence of its degradation products, monoacetyl bisacodyl and Desacetyl Bisacodyl, in enteric coated tablets, suppositories, and raw material. -SCBT Publication Review
Date published: 2015-01-27
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Desacetyl Bisacodyl is rated 5.0 out of 5 by 1.
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