Molecular structure of Derquantel, CAS Number: 187865-22-1
Derquantel (CAS 187865-22-1)
Alternate Names:
Derquantel is also known as 2-Deoxoparaherquamide.
Application:
Derquantel is a semi-synthetic paraherquamide analog and potent nematocide, successfully commercialized in combination with avermectin.
CAS Number:
187865-22-1
Molecular Weight:
479.61
Molecular Formula:
C28H37N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Derquantel is a semi-synthetic paraherquamide analogue prepared by removal of the 2-oxo group in a four-step sequence of N-protection, reduction, N-deprotection and a final reduction. It is a potent nematocide and was the first paraherquamide to be successfully commercialised in combination with avermectin. Derquantel, like other paraherquamides, induces a flaccid paralysis in nematodes thought to be due to inhibition of AChR (nicotinic acetylcholine receptors) acting as an antagonist of acetylcholine.
Derquantel (CAS 187865-22-1) References
- Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep. | Kaminsky, R., et al. 2011. Parasitol Res. 109: 19-23. PMID: 21161271
- Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans. | Ruiz-Lancheros, E., et al. 2011. Int J Parasitol. 41: 455-61. PMID: 21195075
- Efficacy of a combined oral formulation of derquantel-abamectin against the adult and larval stages of nematodes in sheep, including anthelmintic-resistant strains. | Little, PR., et al. 2011. Vet Parasitol. 181: 180-93. PMID: 21684691
- Modelling the benefits of a new class of anthelmintic in combination. | Leathwick, DM. 2012. Vet Parasitol. 186: 93-100. PMID: 22169403
- Comment on: preventive chemotherapy in human helminthiasis: theoretical and operational aspects. | Coles, GC. 2012. Trans R Soc Trop Med Hyg. 106: 327-8. PMID: 22445081
- The efficacy of a combined oral formulation of derquantel-abamectin against anthelmintic resistant gastro-intestinal nematodes of sheep in the UK. | Geurden, T., et al. 2012. Vet Parasitol. 189: 308-16. PMID: 22560330
- Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate. | Sager, H., et al. 2012. Parasitol Res. 111: 2205-7. PMID: 22576857
- New advancement in anthelmintic drugs in veterinary medicine. | Epe, C. and Kaminsky, R. 2013. Trends Parasitol. 29: 129-34. PMID: 23376212
- Derquantel and abamectin: effects and interactions on isolated tissues of Ascaris suum. | Puttachary, S., et al. 2013. Mol Biochem Parasitol. 188: 79-86. PMID: 23523993
- Investigation of acetylcholine receptor diversity in a nematode parasite leads to characterization of tribendimidine- and derquantel-sensitive nAChRs. | Buxton, SK., et al. 2014. PLoS Pathog. 10: e1003870. PMID: 24497826
- Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms. | Li, BW., et al. 2015. Int J Parasitol Drugs Drug Resist. 5: 100-9. PMID: 26199859
- Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms. | Abongwa, M., et al. 2016. PLoS One. 11: e0146854. PMID: 26751958
- Resistance of Haemonchus sp. to monepantel and reduced efficacy of a derquantel / abamectin combination confirmed in sheep in NSW, Australia. | Sales, N. and Love, S. 2016. Vet Parasitol. 228: 193-196. PMID: 27692326
- Functional genomics in Brugia malayi reveal diverse muscle nAChRs and differences between cholinergic anthelmintics. | Verma, S., et al. 2017. Proc Natl Acad Sci U S A. 114: 5539-5544. PMID: 28487481
- Lambs are more stressed at early weaning when housed with their twin. | Casuriaga, D., et al. 2022. Trop Anim Health Prod. 54: 123. PMID: 35235062
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Derquantel, 5 mg | sc-391516 | 5 mg | $520.00 | |||
Derquantel, 25 mg | sc-391516A | 25 mg | $1457.00 |