Deoxyshikonin (CAS 43043-74-9)
Alternate Names:
5,8-Dihydroxy-2-(4-methyl-3-pentenyl)-1,4-naphthalenedione
CAS Number:
43043-74-9
Molecular Weight:
272.30
Molecular Formula:
C16H16O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Deoxyshikonin is a red naphthoquinone pigment that exhibits antioxidant and anti-inflammatory properties. Deoxyshikonin modulates the expression of genes involved in oxidative stress and inflammation. Deoxyshikonin induces apoptosis and inhibits the proliferation of cancer cells. Its mechanism of action involves the regulation of multiple signaling pathways, including NF-κB and MAPK. Deoxyshikonin shows promise as a bioactive compound with potential applications in the fields of inflammation and cancer study.
Deoxyshikonin (CAS 43043-74-9) References
- Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). | Zhang, S., et al. 2015. Front Microbiol. 6: 479. PMID: 26042111
- Wound healing effects of deoxyshikonin isolated from Jawoongo: In vitro and in vivo studies. | Park, JY., et al. 2017. J Ethnopharmacol. 199: 128-137. PMID: 27725239
- Antibacterial and cytotoxic activities of naphthoquinone pigments from Onosma visianii Clem. | Vukic, MD., et al. 2017. EXCLI J. 16: 73-88. PMID: 28435429
- Beneficial Effects of Deoxyshikonin on Delayed Wound Healing in Diabetic Mice. | Park, JY., et al. 2018. Int J Mol Sci. 19: PMID: 30463303
- Deoxyshikonin isolated from Arnebia euchroma inhibits colorectal cancer by down-regulating the PI3K/Akt/mTOR pathway. | Zhu, Y., et al. 2019. Pharm Biol. 57: 412-423. PMID: 31230505
- Deoxyshikonin reversibly inhibits cytochrome P450 2B6. | Kim, JH., et al. 2020. Biopharm Drug Dispos. 41: 221-225. PMID: 32364297
- Deoxyshikonin inhibits cisplatin resistance of non-small-cell lung cancer cells by repressing Akt-mediated ABCB1 expression and function. | Zhang, S. and Wang, Y. 2020. J Biochem Mol Toxicol. 34: e22560. PMID: 32627280
- Discovery of natural products capable of inducing porcine host defense peptide gene expression using cell-based high throughput screening. | Wang, J., et al. 2021. J Anim Sci Biotechnol. 12: 14. PMID: 33431034
- Deoxyshikonin-Induced Gene Expression Profile in Porcine Epithelial Cells. | Wang, J., et al. 2021. Front Vet Sci. 8: 711721. PMID: 35097037
- Deoxyshikonin Mediates Heme Oxygenase-1 Induction and Apoptotic Response via p38 Signaling in Tongue Cancer Cell Lines. | Chuang, CY., et al. 2022. Int J Mol Sci. 23: PMID: 35806120
- Shikonin derivatives as potent xanthine oxidase inhibitors: in-vitro study. | Kumar, N., et al. 2022. Nat Prod Res. 1-6. PMID: 36214700
- Investigation of cytochrome P450 inhibitory properties of deoxyshikonin, a bioactive compound from Lithospermum erythrorhizon Sieb. et Zucc. | Zhang, Y., et al. 2022. Phytother Res.. PMID: 36317387
- Identification of Phytogenic Compounds with Antioxidant Action That Protect Porcine Intestinal Epithelial Cells from Hydrogen Peroxide Induced Oxidative Damage. | Wang, J., et al. 2022. Antioxidants (Basel). 11: PMID: 36358507
- Deoxyshikonin inhibited rotavirus replication by regulating autophagy and oxidative stress through SIRT1/FoxO1/Rab7 axis. | Huang, H., et al. 2023. Microb Pathog. 178: 106065. PMID: 36907361
- In vitro wound healing potential of cyclohexane extract of Onosma dichroantha Boiss. based on bioassay-guided fractionation. | Safavi, F., et al. 2023. Sci Rep. 13: 5018. PMID: 36977702
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Deoxyshikonin, 20 mg | sc-487647 | 20 mg | $400.00 |