Deoxycholic Acid, Sodium Salt is an ionic detergent for the solubilization of membrane-bound proteins. Deoxycholic Acid, Sodium Salt is reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 μM).
1. Pai, Rama., et al., 2004. Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness. Molecular biology of the cell. 15(5): 2156-63. PMID: 15004225
Soluble in water (330 g/l) at 15 °C, DMSO, methanol, and ethanol (very slightly).
Store at room temperature
α20/D +55°, c = 1 in ethanol; α20/D +45.1°, c = 0.98 in methanol; α20/D 44°, c = 2 in water
pKa: 6.58, 6.2, 4.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
Various publications cite the use of SodiumVarious publications cite the use of Sodium deoxycholate (Deoxycholic acid sodium salt), an ionic detergent, for the solubilization of membrane-bound proteins. -SCBT Publication Review
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