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Deoxycholic acid sodium salt (CAS 302-95-4)

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Alternate Names:
Sodium deoxycholate
Application:
Deoxycholic acid sodium salt is an ionic detergent for the solubilization of membrane-bound proteins
CAS Number:
302-95-4
Molecular Weight:
414.55
Molecular Formula:
C24H39O4•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Deoxycholic Acid, Sodium Salt is an ionic detergent for the solubilization of membrane-bound proteins. Deoxycholic Acid, Sodium Salt is reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of beta-catenin signaling (effective concentration 5-50 muM). Deoxycholic acid sodium salt, a derivative of cholic acid found in the gastrointestinal tract, serves as a versatile tool in numerous scientific research applications. Its potent detergent properties enable it to disrupt cell membranes and dissolve hydrophobic molecules effectively. Furthermore, Deoxycholic acid sodium salt finds utility in solubilizing proteins and nucleic acids, as well as in cell lysis processes. In vitro studies extensively rely on this compound for protein and nucleic acid solubilization, as well as cell lysis. Moreover, Deoxycholic acid sodium salt plays a pivotal role in DNA and RNA extraction from cells and tissues. As a result, it has become an invaluable asset in various research endeavors, facilitating the exploration of biological phenomena and the advancement of scientific knowledge.


Deoxycholic acid sodium salt (CAS 302-95-4) References

  1. Expression and purification of growth hormone-releasing factor with the aid of dihydrofolate reductase handle.  |  Iwakura, M., et al. 1992. J Biochem. 112: 57-62. PMID: 1331037
  2. Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness.  |  Pai, R., et al. 2004. Mol Biol Cell. 15: 2156-63. PMID: 15004225
  3. Different stabilities to bile among feline calicivirus strains of respiratory and enteric origin.  |  Mochizuki, M. 1992. Vet Microbiol. 31: 297-302. PMID: 1626378
  4. The effect of bile salts on human vascular endothelial cells.  |  Garner, CM., et al. 1991. Biochim Biophys Acta. 1091: 41-5. PMID: 1995066
  5. Thermodynamic origin of selective binding of β-cyclodextrin derivatives with chiral chromophoric substituents toward steroids.  |  Chen, Y., et al. 2010. J Phys Chem B. 114: 16147-55. PMID: 20695496
  6. Preparation of a nano emodin transfersome and study on its anti-obesity mechanism in adipose tissue of diet-induced obese rats.  |  Lu, K., et al. 2014. J Transl Med. 12: 72. PMID: 24641917
  7. Determination of tamoxifen and its metabolites in human plasma by nonaqueous capillary electrophoresis with contactless conductivity detection.  |  Thang, LY., et al. 2015. Electrophoresis. 36: 2713-2719. PMID: 26174155
  8. Electrokinetic supercharging in nonaqueous capillary electrophoresis for online preconcentration and determination of tamoxifen and its metabolites in human plasma.  |  Thang, LY., et al. 2016. J Chromatogr A. 1461: 185-91. PMID: 27485148
  9. Field-enhanced sample injection-micelle to solvent stacking in nonaqueous capillary electrophoresis.  |  Thang, LY., et al. 2016. Talanta. 161: 165-169. PMID: 27769394
  10. A novel concept of overcoming the skin barrier using augmented liquid nanocrystals: Box-Behnken optimization, ex vivo and in vivo evaluation.  |  Said, M., et al. 2018. Colloids Surf B Biointerfaces. 170: 258-265. PMID: 29935419
  11. Qingyi Decoction amerliorates acute biliary pancreatitis by targeting Gpbar1/NF-kb pathway.  |  Zhang, GX., et al. 2019. Front Biosci (Landmark Ed). 24: 833-848. PMID: 30844716
  12. Method of ultrasound-assisted liquid-phase exfoliation to prepare graphene.  |  Gu, X., et al. 2019. Ultrason Sonochem. 58: 104630. PMID: 31450336
  13. Preparation of pH-sensitive chitosan-deoxycholic acid-sodium alginate nanoparticles loaded with ginsenoside Rb1 and its controlled release mechanism.  |  Dong, Y., et al. 2023. Int J Biol Macromol. 234: 123736. PMID: 36801309

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Deoxycholic acid sodium salt, 25 g

sc-280670
25 g
$85.00

Deoxycholic acid sodium salt, 500 g

sc-280670A
500 g
$850.00

Can this be steam sterilized in the lab?

Asked by: DocL
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-05-17

Do you have data on deoxycholic to reduce pizogenic pedal papules?  

Asked by: Juanita
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service 1
Date published: 2021-02-04
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Rated 5 out of 5 by from Various publications cite the use of SodiumVarious publications cite the use of Sodium deoxycholate (Deoxycholic acid sodium salt), an ionic detergent, for the solubilization of membrane-bound proteins. -SCBT Publication Review
Date published: 2015-06-06
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Deoxycholic acid sodium salt is rated 5.0 out of 5 by 1.
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