densin-180 Antibody (G-1): sc-390153

densin-180 Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects densin-180 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). densin-180 Antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. densin-180 is a crucial synaptic transmembrane protein predominantly located at the postsynaptic density in central nervous system neurons, where densin-180 plays a vital role as a synaptic adhesion molecule. densin-180 is a brain-specific member of the O-sialoglycoprotein family and is characterized by high concentration at synapses along dendrites, which is essential for maintaining synaptic integrity and facilitating communication between neurons. densin-180′s structure includes 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, ZO-1) domain, with the PDZ domain being particularly important for interaction with α-actinin. The intracellular portion of densin-180 interacts with CaMKIIα at distinct binding sites, forming a ternary complex that is stabilized by multiple interactions, underscoring densin-180′s significance in synaptic signaling and plasticity.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

densin-180 Antibody (G-1) References:

1. Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180.  |  Strack, S., et al. 2000. J Biol Chem. 275: 25061-4. PMID: 10827168
2. Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.  |  Walikonis, RS., et al. 2001. J Neurosci. 21: 423-33. PMID: 11160423
3. Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1.  |  Ohtakara, K., et al. 2002. Genes Cells. 7: 1149-60. PMID: 12390249
4. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.  |  Robison, AJ., et al. 2005. J Biol Chem. 280: 35329-36. PMID: 16120608
5. Densin-180: revised membrane topology, domain structure and phosphorylation status.  |  Thalhammer, A., et al. 2009. J Neurochem. 109: 297-302. PMID: 19187442
6. Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.  |  Carlisle, HJ., et al. 2011. J Neurosci. 31: 16194-207. PMID: 22072671
7. Densin-180 is not a transmembrane protein.  |  Liu, DC., et al. 2013. Cell Biochem Biophys. 67: 773-83. PMID: 23516094
8. Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Cav1.2 Ca2+ Channels at Excitatory Synapses.  |  Wang, S., et al. 2017. J Neurosci. 37: 4679-4691. PMID: 28363979
9. Role of densin-180 in mouse ventral hippocampal neurons in 24-hr retention of contextual fear conditioning.  |  Kim, CH., et al. 2020. Brain Behav. 10: e01891. PMID: 33064361
10. Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family.  |  Apperson, ML., et al. 1996. J Neurosci. 16: 6839-52. PMID: 8824323
11. The postsynaptic density at glutamatergic synapses.  |  Kennedy, MB. 1997. Trends Neurosci. 20: 264-8. PMID: 9185308
12. Signal transduction molecules at the glutamatergic postsynaptic membrane.  |  Kennedy, MB. 1998. Brain Res Brain Res Rev. 26: 243-57. PMID: 9651538

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-densin-180 Antibody (G-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-densin-180 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

densin-180 Antibody (G-1) Specifications

Alternate Product Name: densin-180

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 596-895

Epitope Target: densin-180

Epitope Species: rat

Product Reactivity/Detection: densin-180

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for densin-180 Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin